author keywords: cytochrome P450; polycyclic aromatic hydrocarbons; coal tar; DNA adducts; chemical inhibition

MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / drug effects; Benzo(a)pyrene / antagonists & inhibitors; Benzo(a)pyrene / toxicity; Benzopyrenes / toxicity; Carcinogens / antagonists & inhibitors; Carcinogens / toxicity; Coal Tar / chemistry; Complex Mixtures / isolation & purification; Complex Mixtures / pharmacology; Complex Mixtures / standards; Cytochrome P-450 CYP1A1 / antagonists & inhibitors; Cytochrome P-450 CYP1A1 / drug effects; Cytochrome P-450 CYP1B1; DNA / drug effects; DNA / metabolism; DNA Adducts / analysis; Humans; Polycyclic Aromatic Hydrocarbons / isolation & purification; Polycyclic Aromatic Hydrocarbons / pharmacology; Polycyclic Aromatic Hydrocarbons / standards; Tumor Cells, Cultured

TL;DR: The decreases in PAH‐DNA adduct formation on co‐treatment with SRM 1597 revealed inhibitory effects on the CYP enzymes that convert carcinogenic PAH into DNA‐binding metabolites. (via Semantic Scholar)