Tandem C2 domains mediate dynamic organelle targeting of a DOCK family guanine nucleotide exchange factor
Journal of Cell Science, 135(7).
author keywords: DOCK; Rac/Rho-of-plants; Lipid binding; Organelle association; Small GTPases
MeSH headings : C2 Domains; Cytokinesis; Guanine Nucleotide Exchange Factors / metabolism; Monomeric GTP-Binding Proteins / metabolism; Organelles / metabolism
TL;DR:
Mechanistic insight is provided into how DOCK GEFs sense compositional and biophysical membrane properties at the interface of two organelle systems and an evolutionarily conserved and essential localization determinant is uncovered named SPIKE1.
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