2016 review
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
[Review of ]. TRENDS IN MOLECULAR MEDICINE, 22(12), 1077–1090.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / immunology; Bacteria / metabolism; Bacterial Infections / drug therapy; Bacterial Infections / immunology; Bacterial Infections / metabolism; Drug Discovery; Host-Pathogen Interactions / drug effects; Humans; Iron / immunology; Iron / metabolism; Lipocalin-2 / immunology; Lipocalin-2 / metabolism; Siderophores / immunology; Siderophores / metabolism
TL;DR:
This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen sidersophore machinery for the treatment of antibiotic-resistant bacterial infections.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
Iron is an essential nutrient for life. During infection, a fierce battle of iron acquisition occurs between the host and bacterial pathogens. Bacteria acquire iron by secreting siderophores, small ferric iron-binding molecules. In response, host immune cells secrete lipocalin 2 (also known as siderocalin), a siderophore-binding protein, to prevent bacterial reuptake of iron-loaded siderophores. To counter this threat, some bacteria can produce lipocalin 2-resistant siderophores. This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen siderophore machinery for the treatment of antibiotic-resistant bacterial infections. Because the latter reflect a persistent problem in hospital settings, siderophore-targeting or siderophore-based compounds represent a promising avenue to combat such infections.