2012 journal article

The Autoimmune Tautology: An In Silico Approach

Autoimmune Diseases.

Daniel Restrepo-Montoya

TL;DR: The results support the common origin of AIDs and the role of genes involved in apoptosis such as CTLA4, FASLG, and IL10 and find three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 29, 2022

There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published. Thus, our aim was to determine the main shared genes and to what extent they contribute to building clusters of AIDs. We combined a text-mining approach to build clusters of genetic concept profiles (GCPs) from the literature in MedLine with knowledge of protein-protein interactions to confirm if genes in GCP encode proteins that truly interact. We found three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions. After projecting the AIDs on a plane, two clusters could be discerned: Sjögren’s syndrome—systemic lupus erythematosus, and autoimmune thyroid disease—type1 diabetes—rheumatoid arthritis. Our results support the common origin of AIDs and the role of genes involved in apoptosis such asCTLA4,FASLG,andIL10.