MeSH headings : Animals; Antibodies, Anti-Idiotypic / administration & dosage; Antibodies, Anti-Idiotypic / adverse effects; Antibodies, Anti-Idiotypic / immunology; Antibodies, Anti-Idiotypic / therapeutic use; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Epitopes; Female; Immunoglobulin E / immunology; Immunologic Factors / administration & dosage; Immunologic Factors / adverse effects; Immunologic Factors / immunology; Immunologic Factors / therapeutic use; Injections, Subcutaneous; Male

TL;DR: A single injection of monomeric, pegylated scFv with high affinity for dog IgE was demonstrated to be safe and marked reduction in IgE‐bearing lymphocytes and granulocytes accompanied by reduced “free” plasma IgE level in two of four dogs is analogous to omalizumab in humans. (via Semantic Scholar)