2022 article

Non-ergodicity of a globular protein extending beyond its functional timescale

Li, J., Xie, J. F., Godec, A., Weninger, K. R., Liu, C., Smith, J. C., & Hong, L. (2022, August 4). CHEMICAL SCIENCE.

By: J. Li *, J. Xie*, A. Godec *, K. Weninger n , C. Liu *, J. Smith *, L. Hong *

TL;DR: By performing single-molecule fluorescence resonance energy transfer experiments and molecular dynamics simulations of a multi-domain globular protein, cytoplasmic protein-tyrosine phosphatase (SHP2), it is demonstrated that the functional inter-domain motion is observationally non-ergodic over the time spans 10−12 to 10−7 s and 10−1 to 102 s. (via Semantic Scholar)
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Source: Web Of Science
Added: August 22, 2022

Internal motions of folded proteins have been assumed to be ergodic, i.e., that the dynamics of a single protein molecule averaged over a very long time resembles that of an ensemble.