IgD(+) age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged
Kugler-Umana, O., Zhang, W., Kuang, Y., Liang, J., Castonguay, C. H., Tonkonogy, S. L., … Swain, S. L. (2022, September 2). AGING CELL.
author keywords: adaptive immunity; age-associated B cells; aging; influenza; TLR signals
MeSH headings : Animals; Humans; Mice; Antibodies, Viral; Immunoglobulin D; Immunoglobulin G; Immunoglobulin M; Influenza Vaccines; Influenza, Human; Toll-Like Receptor 7; Toll-Like Receptor 9; Vaccines, Inactivated; B-Lymphocytes; T-Lymphocytes
TL;DR:
It is found that in response to influenza, IgD+CD21-CD23-ABC are the precursors of iABC, which is likely the naïve B cells with the potential to become Ab-secreting cells and to provide protection from infection in the aged.
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Added: September 12, 2022