2013 journal article

Cilia and cilia-associated proteins in cancer

Drug Discovery Today: Disease Mechanisms, 10(3-4), e135–e142.

By: T. Seeger-Nukpezah *, J. Little* , V. Serzhanova* & E. Golemis *

TL;DR: Mechanisms by which changes in cilia can contribute to the formation and growth of tumors are discussed, and the cancer-relevance of cilia-dependent signaling pathways and proteins including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9, and Hedgehog are emphasized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: March 1, 2023

The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins, including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9 and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma and breast cancer.