2023 journal article

Cite it

Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Science Advances, 9(8).

By: J. Song ^*, H. Ryu ^*, W. Bai ^*, Z. Xie ^*, A. Vázquez-Guardado^* , K. Nandoliya ^*, R. Avila ^*, G. Lee ^* ...and 16 other authors, Z. Song ^*, J. Kim ^*, M. Lee ^*, Y. Liu ^*, M. Kim ^*, H. Wang ^*, Y. Wu ^*, H. Yoon ^*, S. Kwak ^*, J. Shin ^*, K. Kwon ^*, W. Lu ^*, X. Chen ^*, Y. Huang ^*, G. Ameer ^*, J. Rogers ^*

Contributors: J. Song ^*, H. Ryu ^*, W. Bai ^*, Z. Xie ^*, A. Vázquez-Guardado^* , K. Nandoliya ^*, R. Avila ^*, G. Lee ^* ...and 16 other authors, Z. Song ^*, J. Kim ^*, M. Lee ^*, Y. Liu ^*, M. Kim ^*, H. Wang ^*, Y. Wu ^*, H. Yoon ^*, S. Kwak ^*, J. Shin ^*, K. Kwon ^*, W. Lu ^*, X. Chen ^*, Y. Huang ^*, G. Ameer ^*, J. Rogers ^*

MeSH headings : Mice; Animals; Absorbable Implants; Electric Impedance; Wound Healing; Diabetes Mellitus; Disease Models, Animal; Electric Stimulation Therapy; Inflammation

TL;DR: A miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. (via Semantic Scholar)

10.1126/sciadv.ade4687

Find Text @ NCSU

open access via doi.org (publisher)

PubMed

UN Sustainable Development Goal Categories

3. Good Health and Well-being (OpenAlex)

Source: ORCID

Added: March 14, 2023

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.