2023 review

Current Status of Sub-micron Cavitation-Enhancing Agents for Sonothrombolysis

[Review of ]. ULTRASOUND IN MEDICINE AND BIOLOGY, 49(5), 1049–1057.

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Thrombosis; Sonothrombolysis; Cavitation; Phase-change nanodroplets; Nanoparticles; Nanoemulsions; Contrast agents
MeSH headings : Humans; Ultrasonography; Thrombosis / drug therapy; Ultrasonic Therapy; Fibrinolytic Agents / therapeutic use; High-Intensity Focused Ultrasound Ablation; Mechanical Thrombolysis; Microbubbles; Thrombolytic Therapy
Source: Web Of Science
Added: April 24, 2023

Thrombosis in cardiovascular disease is an urgent global issue, but treatment progress is limited by the risks of current antithrombotic approaches. The cavitation effect in ultrasound-mediated thrombolysis offers a promising mechanical alternative for clot lysis. Further addition of microbubble contrast agents introduces artificial cavitation nuclei that can enhance the mechanical disruption induced by ultrasound. Recent studies have proposed sub-micron particles as novel sonothrombolysis agents with increased spatial specificity, safety and stability for thrombus disruption. In this article, the applications of different sub-micron particles for sonothrombolysis are discussed. Also reviewed are in vitro and in vivo studies that apply these particles as cavitation agents and as adjuvants to thrombolytic drugs. Finally, perspectives on future developments in sub-micron agents for cavitation-enhanced sonothrombolysis are shared. Thrombosis in cardiovascular disease is an urgent global issue, but treatment progress is limited by the risks of current antithrombotic approaches. The cavitation effect in ultrasound-mediated thrombolysis offers a promising mechanical alternative for clot lysis. Further addition of microbubble contrast agents introduces artificial cavitation nuclei that can enhance the mechanical disruption induced by ultrasound. Recent studies have proposed sub-micron particles as novel sonothrombolysis agents with increased spatial specificity, safety and stability for thrombus disruption. In this article, the applications of different sub-micron particles for sonothrombolysis are discussed. Also reviewed are in vitro and in vivo studies that apply these particles as cavitation agents and as adjuvants to thrombolytic drugs. Finally, perspectives on future developments in sub-micron agents for cavitation-enhanced sonothrombolysis are shared.