2023 journal article
Intravascular Sono-Ablation for In-Stent Restenosis Relief: Transducer Development and the In-Vitro Demonstration
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 70(7), 2172–2180.
author keywords: In stent restenosis; focused ultrasound; tissue ablation; interstitial transducer; small aperture
MeSH headings : Humans; Coronary Restenosis; Stents; Computer Simulation; Treatment Outcome
TL;DR:
The developed device can be used for sonoablation of the remaining plaque, providing a novel approach to the treatment of ISR, suggesting it could be as a future ISR treatment modality.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 7, 2023
Objective: This study aimed to propose a new clinical modality for the relief of in-stent restenosis (ISR) using focused ultrasound (FUS) ablation. In the first research stage, a miniaturized FUS device was developed for the sonification of the remaining plaque after stenting, known as one of the causes of ISR. Methods: This study presents a miniaturized (<2.8 mm) intravascular FUS transducer for ISR treatment. The performance of the transducer was predicted through a structural-acoustic simulation, followed by fabrication of the prototype device. Using the prototype FUS transducer, we demonstrated tissue ablation with bio-tissues over metallic stents, mimicking in-stent tissue ablation. Next, we conducted a safety test by detecting the existence of thermal damage to the arterial tissue upon sonication with a controlled dose. Results: The prototype device successfully delivered sufficient acoustic intensity (>30 W/cm2) to a bio tissue (chicken breast) through a metallic stent. The ablation volume was approximately 3.9 × 7.8 × 2.6 mm3. Furthermore, 1.5 min sonication was sufficient to obtain an ablating depth of approximately 1.0 mm, not thermally damaging the underlying artery vessel. Conclusion: We demonstrated in-stent tissue sonoablation, suggesting it could be as a future ISR treatment modality. Significance: Comprehensive test results provide a key understanding of FUS applications using metallic stents. Furthermore, the developed device can be used for sonoablation of the remaining plaque, providing a novel approach to the treatment of ISR.