2024 article

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). NATURE NANOTECHNOLOGY, Vol. 1.

By: M. Liu*, S. Hu* , N. Yan *, K. Popowski n  & K. Cheng*

topics (OpenAlex): Extracellular vesicles in disease; Inhalation and Respiratory Drug Delivery; Nanoplatforms for cancer theranostics
TL;DR: The delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation is reported on and the immunotherapeutic potential of targeted cytokine mRNA therapy is demonstrated, showing the potential for locally delivered cytokine-based immunotherapies to address orthotopic and metastatic lung tumours. (via Semantic Scholar)
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Added: January 29, 2024