2024 article

A compendium of genetic regulatory effects across pig tissues

Teng, J., Gao, Y., Yin, H., Bai, Z., Liu, S., Zeng, H., … Fang, L. (2024, January 4). NATURE GENETICS.

By: J. Jiang  (1 connected NC State author and many others, 102 authors in total )

TL;DR: The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci and cross-species comparisons identify traits with shared genetic regulation in humans. (via Semantic Scholar)
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Source: Web Of Science
Added: February 12, 2024

AbstractThe Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.