2024 journal article

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Mutant Nrf2<SUP>E79Q</SUP> enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors

REDOX BIOLOGY, 75.

By: J. Witherspoon ⁿ, J. Hall ⁿ , D. Jima ⁿ, H. Atkins  ⁿ, N. Wamsley ^*, M. Major ^*, B. Weissman ^*, R. Smart ⁿ 

author keywords: Nrf2; KEAP1; Mouse skin multistage carcinogenesis model; Ras; Papilloma; Squamous cell carcinoma; Proteomics; RNAseq; Cancer; Progression; Conversion; Promotion

10.1016/j.redox.2024.103261

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open access via www.ncbi.nlm.nih.gov (repository)

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2. Zero Hunger (OpenAlex)

3. Good Health and Well-being (Web of Science)

Source: Web Of Science

Added: July 22, 2024

Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway. Constitutive activation is achieved through multiple mechanisms, including activating mutations in NFE2L2 (NRF2). To determine the functional consequences of Nrf2 activation on skin SCC development, we assessed the effects of mutant Nrf2