Pharmacokinetics and ex vivo anti-inflammatory effects of oral misoprostol in horses
EQUINE VETERINARY JOURNAL, 51(3), 415–421.
author keywords: horse; leucocyte; E prostanoid receptor agonist; pharmacokinetics; inflammation; tumour necrosis factor-
MeSH headings : Abortifacient Agents, Nonsteroidal / administration & dosage; Abortifacient Agents, Nonsteroidal / pharmacokinetics; Administration, Oral; Animals; Area Under Curve; Cells, Cultured; Horse Diseases / drug therapy; Horse Diseases / metabolism; Horses / blood; Horses / metabolism; Inflammation / drug therapy; Inflammation / metabolism; Inflammation / veterinary; Leukocytes / drug effects; Leukocytes / metabolism; Misoprostol / administration & dosage; Misoprostol / pharmacokinetics
TL;DR:
Misoprostol is rapidly absorbed following oral administration in horses, and a single 5 μg/kg dose had no significant inhibitory effect on ex vivo LPS‐stimulated TNFα mRNA production in leucocytes.
(via
Semantic Scholar)
UN Sustainable Development Goal Categories