1999 journal article
Assessment of the directional elastic moduli of ewe vertebral cancellous bone by vibrational testing
ANNALS OF BIOMEDICAL ENGINEERING, 27(1), 103–110.
author keywords: postmenopausal osteoporosis; mechanical properties; nondestructive testing; animal model; cellular solid; anisotropy; honeycomb
MeSH headings : Animals; Disease Models, Animal; Elasticity; Female; Humans; Lumbar Vertebrae / pathology; Lumbar Vertebrae / physiology; Lumbar Vertebrae / ultrastructure; Microscopy, Electron, Scanning; Osteoporosis, Postmenopausal / pathology; Osteoporosis, Postmenopausal / physiopathology; Ovariectomy; Sheep; Stress, Mechanical; Vibration
TL;DR:
It is found that ewe vertebral cancellous bone has similar physical and mechanical properties to humans and the vibrational testing method described was able to nondestructively provide a valid measure of stiffness that was correlated with stiffness estimates from traditional compression testing.
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Added: August 6, 2018
The ovariectomized ewe is being used as an animal model for postmenopausal osteoporosis. Data on the mechanical properties of ewe vertebral cancellous bone is needed to assess its effectiveness as a model for vertebral osteoporosis. This study utilized traditional compression testing and a novel nondestructive vibrational testing method to assess the directional mechanical properties of ewe vertebral cancellous bone. Composition and density properties were also assessed. It was hypothesized that vibrational testing would have utility in that it would allow for the anisotropic stiffness of cancellous bone to be assessed nondestructively. The present study has found that ewe vertebral cancellous bone has similar physical and mechanical properties to humans. The vibrational testing method described was able to nondestructively provide a valid measure of stiffness that was correlated with stiffness estimates from traditional compression testing. Furthermore, the stiffness measure from the vibration test was found to be sensitive to the architecture of cancellous bone. These results suggest the promise of this testing method for the nondestructive mechanical assessment of skeletal tissue.