Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
NATURE COMMUNICATIONS , 11 (1).
By: P. Dinh n , D. Paudel n , H. Brochu n , K. Popowski n , M. Gracieux n , J. Cores n , K. Huang n , M. Hensley n ...and 14 other authors, including 9 NC State authors , E. Harrell n , A. Vandergriff n , A. George n , R. Barrio n , S. Hu n , T. Allen n , K. Blackburn n , T. Caranasos * , X. Peng n , L. Schnabel n , K. Adler n , L. Lobo* , M. Goshe n , K. Cheng n
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR:
It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.
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