2020 journal article

Locally delivered minocycline microspheres do not impair osseointegration of titanium implants in a rat femur model

JOURNAL OF ORTHOPAEDICS, 20, 213–216.

By: J. Shapiro*, S. AbuMoussa*, C. Lindsay*, G. Mason*, L. Dahners* & P. Weinhold n

co-author countries: United States of America 🇺🇸
author keywords: Minocycline; Osseointegration; Pushout testing; Bone volume fraction; Sprague-Dawley
Source: Web Of Science
Added: October 12, 2020

The purpose of this study was to determine whether intramedullary administration of extended-release minocycline microspheres would affect osseointegration. Twenty-two rats were randomized to minocycline or saline femoral intramedullary injection followed by implantation of titanium alloy rods. Following euthanasia at four-weeks, pushout testing was performed and bone-volume-fraction assessed. Pushout strength was marginally greater in minocycline-treated implants (122.5 ± 39.1 N) compared to saline (96.9 ± 26.1 N) (P = 0.098). No difference was observed in energy to maximum load, mean stiffness, or peri-implant bone-volume-fraction (P > 0.05). Peri-implant minocycline administration did not impair implant fixation strength or peri-implant bone-volume, supporting its potential utility as an adjunct to intramedullary implants.