Age and Genetic Background Modify Hybrid Male Sterility in House Mice
GENETICS, 216(2), 585–597.
author keywords: hybrid male sterility; aging; genetic background; spermatogenesis; mouse
MeSH headings : Aging / genetics; Aging / physiology; Animals; Female; Genetic Background; Genetic Loci; Hybridization, Genetic; Infertility, Male / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Multifactorial Inheritance
TL;DR:
Results point to multiple segregating HMS modifier alleles, some of which have age-related modes of action, which will advance understanding both of the genetic architecture of HMS and of how reproductive barriers are maintained between house mouse subspecies.
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