This paper summarizes the results of an analytical research program undertaken to develop a rational design procedure for normalweight precast concrete slender spandrel beams. The analytical and rational models use test results and research findings of an extensive experimental program presented in the companion paper "Development of a Rational Design Methodology for Precast Concrete Slender Spandrel Beams: Part 1, Experimental Results," which appeared in the Spring 2011 issue of PCI Journal. The overall research effort demonstrated the validity of using open web reinforcement in precast concrete slender spandrel beams and proposed a simplified procedure for design. The webs of such slender spandrels, particularly in their end regions, are often heavily congested with reinforcing cages when designed with current procedures. The experimental and analytical results demonstrate that open web reinforcement designed according to the proposed procedure is safe and effective and provides an efficient alternative to traditional closed stirrups for precast concrete slender spandrel beams.