2020 journal article

Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

SCIENTIFIC REPORTS, 10(1).

MeSH headings : Animals; Cell Line; Cell Membrane Permeability / drug effects; Doxorubicin / metabolism; Doxorubicin / pharmacology; Duodenum / metabolism; Epithelium / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestine, Small / drug effects; Intestine, Small / metabolism; Jejunum / metabolism; Male; Mice; Mice, Inbred C57BL; Permeability / drug effects; Tight Junctions / metabolism
TL;DR: DXR increases paracellular transit of small macromolecules, including bacterial products, through the epithelium, by altering expression of tight junctional components and dynamic loosening of cellular tight junctions. (via Semantic Scholar)
Source: Web Of Science
Added: January 11, 2021

Abstract