Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment
VETERINARY RADIOLOGY & ULTRASOUND, 62(2), 255–263.
author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli.
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