author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4

MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism

TL;DR: Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli. (via Semantic Scholar)