2021 journal article

Replication of Marek's disease vaccines in turkey embryos and their effect on TLR-3 and IFN-gamma transcripts

AVIAN PATHOLOGY, 50(3), 227–233.

By: I. Gimeno n , W. Shaw n, A. Turner n, J. Bremen n, A. Cortes n, N. Faiz  n, E. Gonder, K. Robbins*

author keywords: HVT; TLR-3; IFN-γ turkey; in ovo; vaccination
topics (OpenAlex): Herpesvirus Infections and Treatments; Cytomegalovirus and herpesvirus research; Animal Virus Infections Studies
TL;DR: It was demonstrated that commercial turkey flocks got exposed to wild type HVT within the first days of life; therefore, there is a potential of interaction between wildtype HVT and rHVT when administered at day of age, and all evaluated vaccines replicated very well in turkey embryonic tissues. (via Semantic Scholar)
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Source: Web Of Science
Added: April 5, 2021

Understanding the pathogenesis of herpesvirus of turkeys (HVT) in its natural host is necessary before recombinant HVT (rHVT) can be used efficiently in turkey flocks. The objectives of this study were to evaluate when commercial turkey flocks get infected with wild type HVT, to study replication of HVT (conventional and recombinant rHVT-Newcastle disease, rHVT-ND) and other Marek's disease (MD) vaccines (SB-1 and CVI988) in turkey embryonic tissues, and to evaluate the expression of TLR-3 and IFN-γ in the lung and spleen of one-day-old turkeys after