author keywords: vaccine evaluation; COVID-19; pandemic; controlled human infection; human challenge trial

MeSH headings : COVID-19; COVID-19 Vaccines; Clinical Trials as Topic; Humans; Pandemics; SARS-CoV-2

TL;DR: It is found that HCTs are likely to be most useful for vaccine candidates currently in preclinical stages of development, and that, while currently limited in their application, there are scenarios in which H CTs would be extremely beneficial. (via Semantic Scholar)