Characterization of IgE-mediated cutaneous immediate and late-phase reactions in nonallergic horses
AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(7), 633–641.
MeSH headings : Animals; Antibodies, Anti-Idiotypic / immunology; Dermatitis / immunology; Dermatitis / veterinary; Eosinophils / immunology; Female; Horse Diseases / chemically induced; Horse Diseases / immunology; Horse Diseases / pathology; Horses / immunology; Immunoglobulin E / immunology; Inflammation / chemically induced; Inflammation / pathology; Inflammation / veterinary; Injections, Intradermal / veterinary; Intradermal Tests / veterinary; Leukocyte Count / veterinary; Male; Neutrophils / immunology; Rabbits; Skin Diseases / chemically induced; Skin Diseases / immunology; Skin Diseases / veterinary; Skin Tests / veterinary
TL;DR:
Injection of anti-IgE antibodies was associated with the development of gross and microscopic inflammation characterized by mast cell degranulation and accumulation of inflammatory cells, particularly eosinophils and neutrophils, which appeared to be similar to that of horses with naturally developing allergic skin disease.
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