2021 journal article
K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15
MOLECULAR BIOLOGY OF THE CELL, 32(22).
MeSH headings : Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Line; Humans; Kidney / cytology; Kinesins / antagonists & inhibitors; Kinesins / genetics; Kinesins / metabolism; Kinetochores; Microtubules / metabolism; Spindle Apparatus / physiology; Time-Lapse Imaging
TL;DR:
The data suggest that forces holding k-fibers together are of similar magnitude to other spindle forces, and that Kif15, acting as a microtubule crosslinker, helps fortify and repair k-Fibers.
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(Web of Science)
Source: Web Of Science
Added: February 21, 2022
The mammalian kinetochore fiber (k-fiber) connects chromosomes to the spindle and supports segregation. We cut k-fibers by laser ablation to probe mechanical connections of microtubules within the bundle. We find that kinesin-12 Kif15 cross-links mediate k-fiber bundling. K-fiber bundling forces are in active competition with forces that cluster microtubule minus-ends.