The ambient environmental conditions, most notably ozone concentration, play a critical role in exacerbating asthma related symptoms. Wearable devices offer a great potential for asthma care and management by tracking health and environmental status. Wearable devices in the form factor of a wristband using ultra-low power ozone sensors can provide a localized, real-time, and vigilant monitoring of users’ ambient environment. This work presents a preliminary investigation of environmental enclosures for such a custom designed wrist-worn wearable device for asthma. Enclosure design plays an important role in ensuring optimal environmental and gas sensor operation. In this study, we studied openings along the sidewall of the wrist-worn device covered with commercially available expanded polytetrafluoroethylene-based membranes to provide the required air flow while ensuring resistance to water.