Abstract One of the largest contributors to the economic loss from floods is the complete or partial destruction of residential buildings, and finding ways to eliminate or minimize this loss is important. Oriented strand board (OSB) is a wood product commonly used in home construction, so a better understanding of how flood water affects its mechanical properties is warranted. In this study, the moduli of elasticity and rupture (MOE and MOR, respectively) of representative samples removed from full-size (4 by 8-ft [1.2 by 2.4 m]) OSB panels were examined following the submergence of the panels in potable and salt water (surrogates for flood water) for increasing periods of time (i.e., 8, 24, 48, 72, 168, and 336 h). The results of our study show that after 8 hours of panel submersion in potable water, MOR and MOE is reduced by 15 percent and 16 percent, respectively; no significant change was observed in MOR and MOE for panels soaked in salt water. After 168 hours, the MOR loss was 43 percent for panels soaked in potable water and 38 percent for panels soaked in salt water. For MOE, there was a 35 percent loss regardless of water type. Submersion of panels in either water type for an additional 168 hours resulted in no significant change in MOR or MOE. The MOR and MOE of samples removed from the edges of the submerged panels, for both water types, were lower than those of the interior samples. Finally, the decreases in average MOR and MOE following submergence in either water type were approximately independent of brand.