author keywords: germ-free mice; interleukin-10; resident bacteria

MeSH headings : Animals; Antigens, Bacterial / immunology; B-Lymphocytes / immunology; Cells, Cultured; Colitis / etiology; Colitis / immunology; Disease Models, Animal; Escherichia coli / immunology; Escherichia coli Infections / complications; Escherichia coli Infections / immunology; Immunity, Mucosal; Interferon-gamma / metabolism; Interleukin-10 / genetics; Interleukin-10 / metabolism; Intestines / immunology; Intestines / microbiology; Lymphocyte Activation; Mice; Mice, 129 Strain; Mice, Knockout; Signal Transduction; Th1 Cells / immunology

TL;DR: Findings show that a resident E. coli that induces chronic colitis in monoassociated IL‐10‐deficient mice rapidly but transiently activates the effector immune system in normal hosts, in parallel with induction of protective IL-10 produced by B cells and CD4+ cells that subsequently suppresses this response to mediate mucosal homeostasis. (via Semantic Scholar)