2022 journal article

Laser ablation reveals the impact of Cdc15p on the stiffness of the contractile ring

MOLECULAR BIOLOGY OF THE CELL, 33(6).

By: M. Moshtohry n, K. Bellingham-Johnstun n, M. Elting n  & C. Laplante n

MeSH headings : Actin Cytoskeleton / metabolism; Cytokinesis; Laser Therapy; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
TL;DR: This work shows that the severed constricting contractile ring recoils to a finite point leaving a gap that can heal if less than ∼1 µm, and proposes that Cdc15p impacts the stiffness of the contractiles ring more than the viscous drag. (via Semantic Scholar)
Source: Web Of Science
Added: June 6, 2022

We use laser ablation to sever the constricting contractile ring of fission yeast cells and reveal the impact of Cdc15p, a putative anchoring protein, on its mechanical properties. Our work suggests that Cdc15p, and thus the anchoring mechanism, impacts the stiffness of the contractile ring more than the viscous drag.