2022 journal article

Total Synthesis of Bipolamine I

Journal of the American Chemical Society.

By: X. Qiu n & J. Pierce n

MeSH headings : Alkaloids; Biological Products; Polymers; Pyrroles; Stereoisomerism
TL;DR: A stereoselective 15-step synthesis of bipolamine I, a distinct member of the broader family, and through this work develop an intermediate that will serve to access other polypyrrole natural products and key analogues going forward. (via Semantic Scholar)
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Source: ORCID
Added: July 6, 2022

Indolizidine alkaloids have been the target of chemical and biological studies for decades, most recently highlighted by the isolation of the curvulamine and bipolamine polypyrrole-containing subclass. Herein we report a stereoselective 15-step synthesis of bipolamine I, a distinct member of the broader family, and through this work develop an intermediate that will serve to access other polypyrrole natural products and key analogues going forward.