TAK1 regulates resident macrophages by protecting lysosomal integrity
CELL DEATH & DISEASE, 8.
MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Embryonic Development / physiology; Lung / metabolism; Lysosomes / metabolism; MAP Kinase Kinase Kinases / metabolism; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Protective Agents / metabolism; Receptors, Tumor Necrosis Factor, Type I / metabolism; Signal Transduction / physiology; Thymocytes / physiology; Thymus Gland / metabolism; Toll-Like Receptors / metabolism
TL;DR:
The results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development, and reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity.
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