2022 article

IgD(+) age-associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged

Kugler-Umana, O., Zhang, W., Kuang, Y., Liang, J., Castonguay, C. H., Tonkonogy, S. L., … Swain, S. L. (2022, September 2). AGING CELL.

By: O. Kugler-Umana *, W. Zhang *, Y. Kuang *, J. Liang*, C. Castonguay*, S. Tonkonogy n, A. Marshak-Rothstein *, P. Devarajan *, S. Swain *

author keywords: adaptive immunity; age-associated B cells; aging; influenza; TLR signals
MeSH headings : Animals; Humans; Mice; Antibodies, Viral; Immunoglobulin D; Immunoglobulin G; Immunoglobulin M; Influenza Vaccines; Influenza, Human; Toll-Like Receptor 7; Toll-Like Receptor 9; Vaccines, Inactivated; B-Lymphocytes; T-Lymphocytes
TL;DR: It is found that in response to influenza, IgD+CD21-CD23-ABC are the precursors of iABC, which is likely the naïve B cells with the potential to become Ab-secreting cells and to provide protection from infection in the aged. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 12, 2022

Abstract