2022 article

FtlA and FtlB Are Candidates for Inclusion in a Next-Generation Multiantigen Subunit Vaccine for Lyme Disease

Camire, A. C., Nathaniel S. O'Bier, Patel, D. T., Cramer, N. A., Straubinger, R. K., Breitschwerdt, E. B., … Marconi, R. T. (2022, September 14). INFECTION AND IMMUNITY.

By: A. Camire*, . Nathaniel S. O'Bier*, D. Patel*, N. Cramer*, R. Straubinger *, E. Breitschwerdt n , R. Funk *, R. Marconi *

author keywords: Borreliella; Borrelia; BBK01; BBG01; Ftl; Lyme disease vaccine; protein family 12; FtlA; Ixodes; Lyme vaccine; PF12; canine Lyme disease; chimeritope
MeSH headings : Animals; Dogs; Antibodies, Bacterial; Antigens, Bacterial; Bacterial Outer Membrane Proteins / genetics; Borrelia burgdorferi; Epitopes; Horses; Immune Sera; Ixodes / microbiology; Lipoproteins / genetics; Lyme Disease / microbiology; Vaccines, Combined; Vaccines, Subunit / genetics
TL;DR: It is suggested that FtlA and FtlB are potential candidates for inclusion in a multivalent vaccine for LD, and epitope localization revealed that the bactericidal epitopes reside within the N-terminal domain of the Ftl proteins. (via Semantic Scholar)
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Source: Web Of Science
Added: September 26, 2022

Lyme disease (LD) is a tick-transmitted bacterial infection caused by Borreliella burgdorferi and other closely related species collectively referred to as the LD spirochetes. The LD spirochetes encode an uncharacterized family of proteins originally designated p rotein f amily t welve (PF12).