Disruption of Trim9 function abrogates macrophage motility in vivo
JOURNAL OF LEUKOCYTE BIOLOGY , 102 (6), 1371–1380.
By: D. Tokarz n , A. Heffelfinger n , D. Jima n , J. Gerlach n , R. Shah n , I. Rodriguez-Nunez n , A. Kortum n , A. Fletcher n ...and 4 other authors, including 2 NC State authors , S. Nordone n , J. Law n , S. Heber n & J. Yoder n
author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo.
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