2022 journal article

Targeted enzyme modifications enable regioselective biosynthesis of fluorinated polyketides

CHEM CATALYSIS, 2(10), 2440–2443.

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 17, 2023

In attempts to enhance natural products as therapeutic agents, fluorination has emerged as a new tool for synthetic biologists and chemists. In recent articles published in Nature Chemistry and Nature Chemical Biology, the Grininger and Chang groups leveraged their expertise in engineering polyketide biosynthesis to incorporate fluorine into polyketide scaffolds.