2022 journal article

Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines


By: H. Brochu n, R. Wang*, T. Tollison n, C. Pyo*, A. Thomas*, E. Tseng*, L. Law*, L. Picker* ...

MeSH headings : Animals; Humans; Alternative Splicing; Cytomegalovirus; Cytomegalovirus Vaccines; Genetic Variation; Macaca mulatta; Simian Immunodeficiency Virus; Histocompatibility Antigens Class I / genetics
TL;DR: Using long-read sequencing, 16 Mamu-E isoforms were identified and all MamU-E splicing junctions were detected among HLA-Eisoforms in humans and the presence of G2_LTR alleles was significantly associated with the lack of RhCMV/SIV vaccine protection. (via Semantic Scholar)
Source: Web Of Science
Added: January 17, 2023