Works (85)
Updated: December 15th, 2024 05:01
2024 journal article
Auranofin is lethal against feline<i> Tritrichomonas</i><i> foetus</i> in vitro but ineffective in cats with naturally occurring infection
VETERINARY PARASITOLOGY, 331.
author keywords: Gold salt; Protozoa; Diarrhea; Ion mobility mass spectrometry; High performance liquid chromatography; Inductively coupled plasma mass spectrometry; Colitis
Sources: Web Of Science, NC State University Libraries
Added: December 9, 2024
2024 article
Measurement of Hydro-EVE and 6:2 FTS in Blood from Wilmington, North Carolina, Residents, 2017-2018
Kotlarz, N., McCord, J., Wiecha, N., Weed, R. A., Cuffney, M., Enders, J. R., … Hoppin, J. A. (2024, February). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 132.
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 21, 2024
2024 journal article
Non-Targeted PFAS Suspect Screening and Quantification of Drinking Water Samples Collected through Community Engaged Research in North Carolina's Cape Fear River Basin
TOXICS, 12(6).
author keywords: community; participatory research; PFAS; mass spectrometry; non-targeted analysis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 1, 2024
2024 article
Reanalysis of PFO5DoA Levels in Blood from Wilmington, North Carolina, Residents, 2017-2018
Kotlarz, N., McCord, J., Wiecha, N., Weed, R. A., Cuffney, M., Enders, J. R., … Hoppin, J. A. (2024, February). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 132.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 21, 2024
2022 journal article
Development and validation of a high resolving power absolute quantitative per- and polyfluoroalkyl substances method incorporating Skyline data processing
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 36(11).
MeSH headings : Chromatography, Liquid; Fluorocarbons; Mass Spectrometry / methods; Reproducibility of Results; Software
TL;DR:
This method demonstrates the feasibility of performing reproducible absolute quantitation of PFAS on an HRAM platform and does so using an open-source vendor-neutral data processing software to facilitate sharing of data across labs and institutions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 4, 2022
2022 article
Recovery of per- and polyfluoroalkyl substances after solvent evaporation
Weed, R. A., Boatman, A. K., & Enders, J. R. (2022, October 14). ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, Vol. 10.
MeSH headings : Fluorocarbons / analysis; Solvents; Bioaccumulation; Fluorine; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 26, 2022
2021 journal article
Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer
Oncotarget, 12(19), 1886–1902.
Contributors: B. Zimmer n, M. Howell *, L. Ma n, n , D. Lehman n, E. Corey *, J. Barycki n, M. Simpson n
TL;DR:
A role for UGDH in androgen responsiveness and a target for therapeutic strategies in advanced prostate cancer is supported by a comparison of protein and metabolite levels relevant to the glucuronidation pathway in patient-derived xenograft models paired with isogenic counterparts selected in vivo for castration resistant prostate cancer recurrence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 16, 2022
2021 journal article
Monitoring decellularization via absorbance spectroscopy during the derivation of extracellular matrix scaffolds
BIOMEDICAL MATERIALS, 17(1).
author keywords: extracellular matrix; manufacturing; decellularization; monitoring; vocal fold
MeSH headings : Biocompatible Materials; Extracellular Matrix / chemistry; Hydrogels; Regenerative Medicine; Spectrum Analysis; Tissue Engineering / methods; Tissue Scaffolds
TL;DR:
Monitoring the bioreactor’s effluent absorbance at 260 nm as a function of time will provide a representative DNA release profile from the tissue and thus allow for process optimization, showing that absorbance profiles are a good representation of DNA removal during the decellularization process thus providing an important tool to optimize future protocols.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 4, 2021
2021 journal article
Ritalinic acid in urine: Impact of age and dose
PRACTICAL LABORATORY MEDICINE, 27.
author keywords: Methylphenidate; Ritalinic acid; LC/MSMS; Urine drug testing
TL;DR:
Study of urine drug testing for ritalinic acid, the major urinary metabolite of methylphenidate (MP), indicates that school age children under the age of 18 have much higher levels of RA than adult patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 23, 2021
2021 article
Understanding the electrospray ionization response factors of per- and poly-fluoroalkyl substances (PFAS)
Enders, J. R., Grace M. O'Neill, Whitten, J. L., & Muddiman, D. C. (2021, July 21). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 7.
author keywords: Electrospray ionization; PFAS; logP; Surface activity
TL;DR:
A method for predicting the behavior of individual PFAS compounds, including relative retention order in chromatography, is presented which is simply based on the number of fluorine atoms in the molecule as well as the class of the compound.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021
2020 journal article
Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 32.
author keywords: Neglected tropical diseases; Chagas' disease; Trypanosoma cruzi; Amastigote; Trypomastigote; Isomerase; Substrate-analogue inhibitors; Competitive inhibition; Trypsin digestion LC-MS/MS
MeSH headings : 3T3 Cells; Aldose-Ketose Isomerases / antagonists & inhibitors; Aldose-Ketose Isomerases / metabolism; Animals; Binding Sites; Catalytic Domain; Drug Design; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Kinetics; Mice; Molecular Dynamics Simulation; Protozoan Proteins / antagonists & inhibitors; Protozoan Proteins / metabolism; Substrate Specificity; Trypanocidal Agents / chemical synthesis; Trypanocidal Agents / metabolism; Trypanocidal Agents / pharmacology; Trypanosoma cruzi / drug effects; Trypanosoma cruzi / enzymology
TL;DR:
The study of Compound B served as a proof-of-concept so that next generation inhibitors can potentially be developed with a focus on using a prodrug group in replacement of the iodoacetamide moiety, thus representing an attractive starting point for the future treatment of Chagas' disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 15, 2020
2020 journal article
Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues.
ACS Biomaterials Science & Engineering, 6(7), 4200–4213.
author keywords: automation; decellularization; extracellular matrix; hydrogel; biomaterial; biofabrication
MeSH headings : Animals; Biocompatible Materials; Bioreactors; Extracellular Matrix; Hydrogels; Swine; Tissue Scaffolds
TL;DR:
This work presents a versatile, scalable, and automated platform for the rapid production of ECM scaffolds with a biofabrication method for fast and automated derivation of raw material for ECM hydrogel production while preserving ECM composition and controlling lot-to-lot variability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 16, 2020
2020 journal article
Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-β1-Mediated Fibroblast Activation in Vitro.
ACS Biomaterials Science & Engineering, 6(3), 1690–1703.
author keywords: extracellular matrix; hydrogels; vocal fold lamina propria; MBVs; fibrosis
MeSH headings : Animals; Biocompatible Materials / pharmacology; Fibroblasts; Mucous Membrane; Swine; Transforming Growth Factor beta1; Vocal Cords
TL;DR:
The results provide evidence of the unique protein composition of the VFLP-ECM and the potential link between the components of the vesicles and macromolecules and the inhibition of TGF-β1 signaling observed in vitro when transformed into injectable forms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: February 13, 2020
2019 journal article
A Dilute and Shoot LC-MS/MS Method for Antipsychotics in Urine
JOURNAL OF ANALYTICAL TOXICOLOGY, 44(4), 331–338.
MeSH headings : Antipsychotic Agents / urine; Aripiprazole; Chromatography, Liquid; Drug Monitoring; Humans; Limit of Detection; Quinolones; Tandem Mass Spectrometry; Thiophenes
TL;DR:
A dilute and shoot method for the analysis of 19 different antipsychotics and metabolites takes advantage of earlier reports demonstrating unique, prevalent urine metabolites for aripiprazoles, brexpiprazole, haloperidol, and lurasidone to enhance sensitivity for these analytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 22, 2020
2019 conference paper
A Dilute-and-Shoot LC-MS/MS Method for Antipsychotics in Urine
Feng, S., Enders, J., Cummings, O. T., Strickland, E. C., McIntire, T., & McIntire, G. (2019, October). Presented at the Society of Forensic Toxicology (SOFT) Annual Meeting, San Antonio, TX.
Event: Society of Forensic Toxicology (SOFT) Annual Meeting at San Antonio, TX
Source: NC State University Libraries
Added: May 3, 2021
2019 conference paper
A Proteomic Investigation of Changes in the Collagen Types Present in the Anterior Cruciate Ligament During Post-natal Growth
Enders, J. R., Cone, S. G., & Fisher, M. B. (2019, June). Presented at the American Society for Mass Spectrometry (ASMS) Annual Conference, Atlanta, GA.
Event: American Society for Mass Spectrometry (ASMS) Annual Conference at Atlanta, GA
Source: NC State University Libraries
Added: May 3, 2021
2019 journal article
Determination of the Relative Prevalence of Lurasidone Metabolites in Urine Using Untargeted HRMS
Current Trends in Mass Spectrometry, 17(2), 8–15. http://www.spectroscopyonline.com/determination-relative-prevalence-lurasidone-metabolites-urine-using-untargeted-hrms-0
Source: NC State University Libraries
Added: November 16, 2020
2019 article
Experimental data demonstrating the effects of silver nanoparticles on basement membrane gene and protein expression in cultured colon, mammary and bronchial epithelia
Yeyeodu, S. T., Martin, M. E., Reaves, D. K., Enders, J. R., Costantini, L. M., & Fleming, J. M. (2019, October). DATA IN BRIEF, Vol. 26.
author keywords: Silver nanoparticles; Epithelial cells; Basement membrane; Extracellular matrix; TGF-Beta; Intracellular signalling pathway analysis
TL;DR:
Ingenuity pathway analysis (IPA) of combined gene and protein expression datasets was then used to predict canonical pathways affected by AgNP exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 25, 2019
2019 journal article
Silver nanoparticles alter epithelial basement membrane integrity, cell adhesion molecule expression, and TGF-β1 secretion
Nanomedicine: Nanotechnology, Biology and Medicine, 21, 102070.
author keywords: Silver nanoparticles; Epithelial cells; Basement membrane; Extracellular matrix; CD44; Transforming growth factor-beta
MeSH headings : Basement Membrane / metabolism; Cell Adhesion Molecules / biosynthesis; Cell Line, Tumor; Gene Expression Regulation / drug effects; Humans; Metal Nanoparticles / chemistry; Silver / chemistry; Silver / pharmacology; Transforming Growth Factor beta1 / biosynthesis
TL;DR:
Results indicate AgNP exposure interferes with BM and cell adhesion dynamics, and provide insight into the mechanisms of AgNP-induced disruption of epithelial physiology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 3, 2020
2018 journal article
Alginate-encapsulated primary human hepatocyte culture system to increase the accuracy of the predicted in vivo half-life of low clearance compounds
Drug Metabolism and Pharmacokinetics, 33(1), S69–S70.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 3, 2020
2018 journal article
Analytical Considerations When Developing an LC-MS/MS Method for Over 30 Analytes
The Journal of Applied Laboratory Medicine, 2(4), 543–554.
TL;DR:
The method presented herein provides quality results and accurate medication monitoring by use of novel approaches to calibration curves and controls that both improve performance and minimize risk (financial and operational).
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 16, 2020
2018 conference paper
Investigation of a targeted protein panel of diagnostic and prognostic value to ALS in biological fluids
Enders, J. (2018, June). Presented at the Qualitative Biomarkers, The American Society for Mass Spectrometry (ASMS) Annual Conference, San Diego, CA.
Event: Qualitative Biomarkers, The American Society for Mass Spectrometry (ASMS) Annual Conference at San Diego, CA
Source: NC State University Libraries
Added: May 3, 2021
2018 journal article
Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS
SCIENTIFIC REPORTS, 8(1).
Contributors: M. Bereman n, J. Beri n, n & T. Nash n
MeSH headings : Amyotrophic Lateral Sclerosis / blood; Amyotrophic Lateral Sclerosis / cerebrospinal fluid; Amyotrophic Lateral Sclerosis / metabolism; Humans; Machine Learning; Multivariate Analysis; Proteomics
TL;DR:
The potential of a panel of targeted proteins for objective measurements of clinical value in ALS is demonstrated, and three proteins composed a prognostic model that explained 49% of the variation in the ALS-FRS scores.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 19, 2018
2018 patent
NORMALIZING MEASURED DRUG CONCENTRATIONS IN ORAL FLUIDS AND TESTING FOR POTENTIAL NON-COMPLIANCE WITH DRUG TREATMENT REGIMEN
https://www.lens.org/109-358-919-977-271
Source: ORCID
Added: July 16, 2022
2018 report
Normalizing measured drug concentrations in oral fluids and testing for potential non-compliance with drug treatment regimen
(U.S. Patent Application Number No. 2018/20180045744 A1.).
Source: NC State University Libraries
Added: May 3, 2021
2018 journal article
Xenobiotic Metabolism in Alginate-Encapsulated Primary Human Hepatocytes over Long Timeframes
Applied In Vitro Toxicology, 4(3), 238–247.
Contributors: M. Phillips *, P. Balbuena-Venancio*, * , R. Norini*, Y. Shim*, E. Burgunder*, L. Rao*, D. Billings*
Source: ORCID
Added: December 11, 2019
2017 conference paper
Evaluation of Non-Specific Binding to Different Organic Polymeric Components in Flow-Based Advanced Cell Culture Systems for Toxicity Testing
Enders, J. R., Balbuena-Venancio, P., Billings, D., Rao, L., Burgunder, E., Phillips, M., & Yoon, M. (2017, March). Presented at the Society of Toxicology (SOT) Annual Conference, Baltimore, MD.
Event: Society of Toxicology (SOT) Annual Conference at Baltimore, MD
Source: NC State University Libraries
Added: May 3, 2021
2017 journal article
Identification of metabolites of brexpiprazole in human urine for use in monitoring patient compliance
Clinical Mass Spectrometry, 6, 21–24.
author keywords: Brexpiprazole Metabolites; OPC-3952; Medication monitoring
TL;DR:
The use of OPC-3952 in urine, as an indicator of compliance, provides a potential avenue for improved monitoring of patients who have been prescribed brexpiprazole.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2017 journal article
Impact of β-Glucuronidase Mediated Hydrolysis on Haldol® Urinalysis
Journal of Analytical Toxicology, 42(4), 214–219.
MeSH headings : Chromatography, Liquid; Glucuronidase / metabolism; Haloperidol / urine; Humans; Hydrolysis; Tandem Mass Spectrometry; Urinalysis / methods
TL;DR:
This work shows that high levels of the glucuronidated form of haloperidol are present in patient urine samples, and demonstrates that hydrolysis greatly improves the sensitivity and consistency of results for patients on haloperIDol therapy resulting in positivity data that strongly correlates with the dosage form administered.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2017 patent
METHODS OF MONITORING ADHERENCE TO LURASIDONE THERAPY
https://www.lens.org/119-736-087-516-250
Source: ORCID
Added: July 16, 2022
2017 patent
METHODS OF MONITORING FOR ADHERENCE TO BREXPIPRAZOLE (REXULTI®) THERAPY
https://www.lens.org/141-517-997-208-481
Source: ORCID
Added: July 16, 2022
2017 report
Methods of Monitoring Adherence to Lurasidone Therapy
(U.S. Patent No. 2015/0168431 A1).
Source: NC State University Libraries
Added: May 3, 2021
2017 report
Methods of Monitoring for Adherence to Brexpiprazole (Rexulti®) Therapy
(U.S. Patent Application No. 2017/0276692 A1).
Source: NC State University Libraries
Added: May 3, 2021
2017 patent
Methods of monitoring adherence to lurasidone therapy
https://www.lens.org/102-095-827-858-797
Source: ORCID
Added: July 16, 2022
2017 journal article
Response to: Fentanyl-Norfentanyl concentrations during transdermal patch application: LC-MS-MS urine analysis
Journal of Analytical Toxicology, 41(2), 165–166. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019570326&partnerID=MN8TOARS
Source: ORCID
Added: December 11, 2019
2016 journal article
Fentanyl-norfentanyl concentrations during transdermal patch application: LC-MS-MS urine analysis
Journal of Analytical Toxicology, 40(8), 595–600.
MeSH headings : Administration, Cutaneous; Adult; Aged; Chromatography, Liquid; Female; Fentanyl / administration & dosage; Fentanyl / analogs & derivatives; Fentanyl / urine; Humans; Male; Middle Aged; Models, Theoretical; Retrospective Studies; Substance Abuse Detection; Tandem Mass Spectrometry; Transdermal Patch
TL;DR:
This work examines a larger population of patient positives for fentanyl and norfentanyl to determine whether more than a decade later the original report remains accurate in predicting the range and median levels of fentanyl and Norfentanyl concentrations physicians can expect to see from their patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2016 conference paper
Fentanyl—Norfentanyl Concentrations During Transdermal Patch Application: LC-MS/MS Urine Analysis
Presented at the Society of Forensic Toxicology (SOFT) Annual Meeting, Dallas, TX.
Event: Society of Forensic Toxicology (SOFT) Annual Meeting at Dallas, TX
Source: NC State University Libraries
Added: August 13, 2021
2016 journal article
Improved chiral separation of methamphetamine enantiomers using CSP-LC-MS-MS
Journal of Analytical Toxicology, 40(4), 255–263.
Contributors: L. Ward, * , D. Bell *, H. Cramer*, F. Wallace & G. McIntire
MeSH headings : Calibration; Chromatography, Gas; Chromatography, High Pressure Liquid; Fluoroacetates / chemistry; Humans; Indicators and Reagents; Limit of Detection; Methamphetamine / chemistry; Methamphetamine / isolation & purification; Methamphetamine / urine; Reproducibility of Results; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry
TL;DR:
The comparative analysis of the samples run by GC and LC methods showed preferential bias of the GC method for producing error rates, consistent with previous research, while the CSP-LC-MS-MS method produces percent deviation errors of <2%.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
2016 conference paper
Investigation of a Large Pain Profile from Fingerstick Capillary Blood
New Approaches to Pain Medication Compliance Monitoring. Presented at the Association for Mass Spectrometry and Advances in the Clinical Lab (MSACL) 2016 US: 8th Annual Congress and Exhibits, Palm Springs, CA.
Event: Association for Mass Spectrometry and Advances in the Clinical Lab (MSACL) 2016 US: 8th Annual Congress and Exhibits at Palm Springs, CA on February 21-25, 2016
Source: NC State University Libraries
Added: August 13, 2021
2016 patent
NORMALIZING MEASURED DRUG CONCENTRATIONS IN ORAL FLUIDS AND TESTING FOR POTENTIAL NON-COMPLIANCE WITH DRUG TREATMENT REGIMEN
https://www.lens.org/173-764-751-938-731
Source: ORCID
Added: July 16, 2022
2016 journal article
Normalizing oral fluid hydrocodone data using calculated blood volume
Journal of Analytical Toxicology, 40(7), 486–491.
MeSH headings : Analgesics, Opioid / metabolism; Humans; Hydrocodone / metabolism; Saliva / metabolism; Substance Abuse Detection / methods
TL;DR:
A retrospective approach to transform and normalize oral fluid testing results to provide a historical picture of patient values in this important test fluid, which parallels the use of creatinine to normalize drug concentration levels in urine and is consistent with the view that oral fluid samples reflect plasma concentrations of the respective drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2016 journal article
The synthetic cannabinoid chemical arms race and its effect on pain medication monitoring
LC-GC North America, 34(4), 15–22.
Source: NC State University Libraries
Added: November 16, 2020
2015 journal article
A dilute-and-shoot LC-MS method for quantitating opioids in oral fluid
Journal of Analytical Toxicology, 39(8), 662–667.
MeSH headings : Analgesics, Opioid / analysis; Chromatography, Liquid / methods; Humans; Limit of Detection; Saliva / chemistry; Tandem Mass Spectrometry / methods
TL;DR:
A fast, 'dilute-and-shoot' method that removes the unnecessary, costly and time-consuming extraction steps found in traditional methods and still surpasses all analytical requirements is highlighted.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
2015 journal article
An Initial Look at Ketamine and Norketamine: Levels in a Pain Management Population
ToxTalk, 39(3), 7–10. https://www.soft-tox.org/files/toxtalk/SOFT_ToxTalk_v39-3.pdf
Source: NC State University Libraries
Added: November 16, 2020
2015 journal article
Haldol Analysis in Urine: The Impact of Beta-Glucuronidase Hydrolysis
ToxTalk, 39(3), 12–14. https://www.soft-tox.org/files/toxtalk/SOFT_ToxTalk_v39-3.pdf
Source: NC State University Libraries
Added: November 16, 2020
2015 patent
METHODS OF MONITORING ADHERENCE TO LURASIDONE THERAPY
https://www.lens.org/142-044-808-933-676
Source: ORCID
Added: July 16, 2022
2015 journal article
Rapid Analysis of Selected Benzodiazepines by Automated SPE-MS/MS
Current Trends in Mass Spectrometry, 13(2), 8–15. https://www.chromatographyonline.com/view/rapid-analysis-selected-benzodiazepines-automated-spe-ms-ms
Source: NC State University Libraries
Added: November 16, 2020
2015 conference paper
Rapid Mass Spectrometry Based Urine Drug Screening of 27 Antipsychotic and Antidepressant Medications
Presented at the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) 7th Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) 7th Annual Conference at San Diego, CA on March 28 - April 1, 2015
Source: NC State University Libraries
Added: March 12, 2022
2015 journal article
Real-time cellular exometabolome analysis with a microfluidic-mass spectrometry platform
PLoS ONE, 10(2).
Contributors: C. Marasco *, * , K. Seale*, J. McLean * & J. Wikswo *
MeSH headings : Cocaine / metabolism; Extracellular Space / metabolism; Humans; Jurkat Cells; Mass Spectrometry / methods; Metabolome; Metabolomics / methods; Microfluidics / methods; Solid Phase Extraction / methods; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The UPLC-ESI-IM-MS platform proved capable of detecting metabolomic variations between naïve and experienced Jurkat T cells and highlights the dynamics of the exometabolome over time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 11, 2019
2014 conference paper
Cross-Platform Comparison of Rapid Benzodiazepine Analyses
Presented at the Society of Forensic Toxicology (SOFT) Annual Meeting, Grand Rapids, MI.
Event: Society of Forensic Toxicology (SOFT) Annual Meeting at Grand Rapids, MI
Source: NC State University Libraries
Added: March 12, 2022
2014 conference paper
Easy to Automate Extraction of THC Metabolites for LC-MS/MS Analysis
Presented at the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference at San Diego, CA
Source: NC State University Libraries
Added: March 12, 2022
2014 conference paper
Oral Fluid Pain Management Panel by "Dilute and Shoot" LC-MS/MS
Presented at the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference at San Diego, CA
Source: NC State University Libraries
Added: March 12, 2022
2014 conference paper
Oral Fluid Testing for Buprenorphine and THC by "Dilute and Shoot LC-MS/MS
Presented at the 62nd American Society for Mass Spectrometry (ASMS) Annual Conference, Baltimore, MD.
Event: 62nd American Society for Mass Spectrometry (ASMS) Annual Conference at Baltimore, MD
Source: NC State University Libraries
Added: March 12, 2022
2014 conference paper
Oral Fluid Testing for Opiates by Dilute and Shoot LC-MS/MS
Presented at the Society of Forensic Toxicology (SOFT) Annual Meeting, Grand Rapids, MI.
Event: Society of Forensic Toxicology (SOFT) Annual Meeting at Grand Rapids, MI
Source: NC State University Libraries
Added: March 12, 2022
2014 speech
Quantitative Analysis using Rapid Technologies
(2014, October). In Rapid Urine Drug Testing by Mass Spectrometry. Workshop presented at the Society of Forensic Toxicology (SOFT) Annual Meeting, Grand Rapids, MI.
Event: Society of Forensic Toxicology (SOFT) Annual Meeting at Grand Rapids, MI
Source: NC State University Libraries
Added: March 12, 2022
2014 conference paper
Rapid Analysis of Selected Benzodiazepines by Automated SPE/MS/MS
Presented at the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference at San Diego, CA
Source: NC State University Libraries
Added: March 12, 2022
2014 journal article
Screening Analysis of Heroin Samples for Possible Cutting Agents and Adulterants
ToxTalk, 38(3), 12–16. https://www.soft-tox.org/files/toxtalk/SOFT_ToxTalk_v38-3.pdf
Source: NC State University Libraries
Added: November 16, 2020
2013 conference paper
A Quantitative Inspection of ESI Glucuronide Degradation
Presented at the 61st American Society for Mass Spectrometry Annual Conference, Minneapolis, MN.
Event: 61st American Society for Mass Spectrometry Annual Conference at Minneapolis, MN
Source: NC State University Libraries
Added: March 12, 2022
2012 journal article
A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry
Analytical Chemistry, 84(20), 8467–8474.
Contributors: * , C. Marasco *, J. Wikswo * & J. McLean *
MeSH headings : Bioreactors; Equipment Design; Mass Spectrometry / instrumentation; Microfluidic Analytical Techniques / instrumentation; Salts / isolation & purification; Solid Phase Extraction / instrumentation
TL;DR:
This work demonstrates that this dual-column online solid phase extraction (SPE) approach may be used for flow rates as low as 500 nL/min, with temporal resolving power on the order of 3 min, with analyte loadings ranging from femtomoles to picomoles for metabolites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 11, 2019
2012 conference paper
Development of a Platform for Online Analysis of the Metabolic Footprint
Presented at the Association for Mass Spectrometry: Applications to the Clinical Laboratory (MSACL) Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry: Applications to the Clinical Laboratory (MSACL) Annual Conference at San Diego, CA
Source: NC State University Libraries
Added: March 12, 2022
2012 entry reference
Multidimensional Separations by Ion Mobility-Mass Spectrometry
TL;DR:
The unique advantages of IM-MS in biological fields ranging from systems biology to structural biology are introduced, the context of which is introduced by a historical perspective of key advances accomplished over the last century.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 4, 2020
2012 conference paper
Online analysis of a constant-perfusion cell culture microfluidic device for exometabolomic measurements
Presented at the 60th American Society for Mass Spectrometry Annual Conference, Vancouver, BC.
Event: 60th American Society for Mass Spectrometry Annual Conference at Vancouver, BC
Source: NC State University Libraries
Added: March 12, 2022
2012 conference paper
Strategies and Challenges in Dynamic Systems Biology Analysis Using Structural Mass Spectrometry”
Strategies and Challenges in Dynamic Systems Biology Analysis Using Structural Mass Spectrometry.” Ion Mobility MS: Applying Ion Mobility-Mass Spectrometry to Challenges in Proteomics and Systems Biology. Workshop presented at the American Society for Mass Spectrometry (ASMS) Annual Conference, Vancouver, BC Canada.
Event: American Society for Mass Spectrometry (ASMS) Annual Conference at Vancouver, BC Canada
Source: NC State University Libraries
Added: March 12, 2022
2011 conference paper
A Microfluidic-Ion Mobility-Mass Spectrometry Platform for Presymptomatic Diagnoses of CBW Agent Exposure
Presented at the 2011 Chemical and Biological Defense Science and Technology Conference, Las Vegas, NV.
Event: 2011 Chemical and Biological Defense Science and Technology Conference at Las Vegas, NV
Source: NC State University Libraries
Added: March 12, 2022
2011 journal article
Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from Haystacks
Current Trends in Mass Spectrometry, 9(3), 18–23.
Source: NC State University Libraries
Added: November 16, 2020
2011 conference paper
Development of a Platform for Online Acquisition of Empirical Systems Biology Data
Presented at the 5th Annual Conference on Cellular Information Processing (q-bio), Santa Fe, NM.
Event: 5th Annual Conference on Cellular Information Processing (q-bio) at Santa Fe, NM on August 10-14, 2011
Source: NC State University Libraries
Added: March 12, 2022
2011 conference paper
Microfluidic-Coupled Ion Mobility-Mass Spectrometry Platform for Real-Time, Temporally-Resolved Analysis of Excreted Cellular Materials
Presented at the 59th American Society for Mass Spectrometry Annual Conference, Denver, CO.
Event: 59th American Society for Mass Spectrometry Annual Conference at Denver, CO
Source: NC State University Libraries
Added: March 12, 2022
2011 chapter
Peptide and Protein Analysis Using Ion Mobility-Mass Spectrometry
In Protein and Peptide Mass Spectrometry in Drug Discovery (pp. 139–174).
Contributors: * , M. Kliman*, S. Sundarapandian * & J. Mclean *
Source: ORCID
Added: December 11, 2019
2010 conference paper
Advanced Structural Mass Spectrometry for Systems Biology – Towards Presymptomatic Diagnosis of Threat Agent Exposure
Presented at the Chemical and Biological Defense Science & Technology Conference, Orlando, FL.
Event: Chemical and Biological Defense Science & Technology Conference at Orlando, FL
Source: NC State University Libraries
Added: March 12, 2022
2010 conference paper
Characterizing the Saccharomyces cerevisiae respiratory oscillation exometabolome by ion mobility-mass spectrometry
Presented at the Quantitative Understanding in Biology (q-bio) Annual Conference, Santa Fe, NM.
Event: Quantitative Understanding in Biology (q-bio) Annual Conference at Santa Fe, NM
Source: NC State University Libraries
Added: March 12, 2022
2010 conference paper
Development of a Multi-Channel Ion Mobility-Mass Spectrometer for High-Throughput Interrogation of Cellular Response
Presented at the Quantitative Understanding in Biology (q-bio) Annual Conference, Santa Fe, NM.
Event: Quantitative Understanding in Biology (q-bio) Annual Conference at Santa Fe, NM
Source: NC State University Libraries
Added: March 12, 2022
2010 conference paper
Development of a Multiplexed (8-Channel) Ion Mobility-Mass Spectrometer Chemical Analyzer for Rapid Interrogation of Biochemical Response
Presented at the Chemical and Biological Defense Science & Technology Conference, Orlando, FL.
Event: Chemical and Biological Defense Science & Technology Conference at Orlando, FL
Source: NC State University Libraries
Added: March 12, 2022
2010 conference paper
High-Throughput Ion Mobility-Mass Spectrometry Strategies for Monitoring Cellular Response in Real Time
Presented at the 58th Annual American Society for Mass Spectrometry Annual Conference, Salt Lake City, UT.
Event: 58th Annual American Society for Mass Spectrometry Annual Conference at Salt Lake City, UT
Source: NC State University Libraries
Added: March 12, 2022
2010 conference paper
Investigating Leukocyte Dynamic Response to Stimuli in an Integrated Microfluidic-Ion Mobility-Mass Spectrometer
Presented at the Quantitative Understanding in Biology (q-bio) Annual Conference, Santa Fe, NM.
Event: Quantitative Understanding in Biology (q-bio) Annual Conference at Santa Fe, NM
Source: NC State University Libraries
Added: March 12, 2022
2010 book
Structurally selective imaging mass spectrometry by imaging ion mobility-mass spectrometry
In Methods in Molecular Biology (Vol. 656, pp. 363–383).
Contributors: J. McLean *, L. Fenn* & *
author keywords: Ion mobility; ion mobility-mass spectrometry; IM-MS; imaging mass spectrometry; IMS; MSI; imaging ion mobility-mass spectrometry; structural separations; MALDI; IM-MS/MS
MeSH headings : Diagnostic Imaging / methods; Ions / chemistry; Lipids / chemistry; Mass Spectrometry / methods; Peptides / chemistry; Proteins / chemistry; Tandem Mass Spectrometry
TL;DR:
This chapter describes the utility of structurally based separations combined with imaging mass spectrometry (MS) by ion mobility-MS (IM-MS) approaches and special emphasis is placed on the use of imaging IM-MS for the analysis of samples in life sciences research.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
2010 conference paper
Temporal Analysis of Biological Fluid for the Analysis of Cellular Signaling and Response Using Ion Mobility-mass Spectrometry Analyses
Presented at the Chemical and Biological Defense Science & Technology conference, Orlando, FL.
Event: Chemical and Biological Defense Science & Technology conference at Orlando, FL
Source: NC State University Libraries
Added: March 12, 2022
2010 journal article
Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform
IET Systems Biology, 4(6), 416–427.
Contributors: * , C. Marasco *, A. Kole *, B. Nguyen *, S. Sevugarajan*, K. Seale*, J. Wikswo *, J. McLean *
MeSH headings : Cell Biology / instrumentation; Cell Physiological Phenomena; Cell Separation / instrumentation; Cells / chemistry; Cells / cytology; Humans; Jurkat Cells; Microfluidic Analytical Techniques / methods; Saccharomyces cerevisiae; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Systems Biology / methods
TL;DR:
Preliminary experiments examining peptides in methanol and recording the interactions of yeast and Jurkat cells with their superfusate have identified instrumental set-up and control parameters and online desalting procedures that demonstrate and validate this new instrumental platform.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
2009 journal article
Chiral and structural analysis of biomolecules using mass spectrometry and ion mobility-mass spectrometry
Chirality, 21(1 E).
Contributors: * & J. Mclean *
author keywords: chirality; mass spectrometry; ion mobility; ion mobility-mass spectrometry; structural separations; peptide; protein
MeSH headings : Carbohydrates / chemistry; Ions / chemistry; Kinetics; Lipids / chemistry; Mass Spectrometry / methods; Models, Chemical; Molecular Structure; Nucleotides / chemistry; Peptides / chemistry; Stereoisomerism; Thermodynamics
TL;DR:
This report describes the strategies for gas-phase chiral and structural characterization of biomolecules using mass spectrometry (MS) and ion mobility-MS (IM-MS) techniques and methodologies for adding a chiral selector are discussed.
(via Semantic Scholar)
Source: ORCID
Added: December 11, 2019
2009 conference paper
Combining microfluidic cell trapping with real time monitoring of biomolecular exudates by ion mobility-mass spectrometry
Presented at the American Society for Mass Spectrometry Annual Conference, Philadelphia, PA.
Event: American Society for Mass Spectrometry Annual Conference at Philadelphia, PA
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Measuring real-time cellular responses to chemical and biological warfare agents using structural mass spectrometry techniques
Presented at the Chemical and Biological Defense Science and Technology (CBD S&T) Conference, Dallas, TX.
Event: Chemical and Biological Defense Science and Technology (CBD S&T) Conference at Dallas, TX
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Microfluidic-ion mobility-mass spectrometry for assessing cellular response in real time
Presented at the Quantitative Understanding in Biology (q-bio) Annual Conference, Santa Fe, NM.
Event: Quantitative Understanding in Biology (q-bio) Annual Conference at Santa Fe, NM
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Microfluidic-ion mobility-mass spectrometry for assessing cellular response in real time
Presented at the Quantitative Understanding in Biology (q-bio) Annual Conference, Santa Fe, NM.
Event: Quantitative Understanding in Biology (q-bio) Annual Conference at Santa Fe, NM
Source: NC State University Libraries
Added: March 12, 2022
2009 conference paper
Real time analysis of cell signaling and response using microfluidic cell trapping-ion mobility-mass spectrometry
Presented at the Federation of Analytical Chemistry and Spectroscopy Societies Conference, Louisville, KY.
Event: Federation of Analytical Chemistry and Spectroscopy Societies Conference at Louisville, KY
Source: NC State University Libraries
Added: March 12, 2022
2008 conference paper
Dynamic Biomolecular Measurements of Cellular Response by Ion Mobility-Mass Spectrometry: A New Strategy for Systems Biology
Presented at the Southeast Regional Meeting of the American Chemical Society, Nashville, TN.
Event: Southeast Regional Meeting of the American Chemical Society at Nashville, TN
Source: NC State University Libraries
Added: March 12, 2022
2008 conference paper
Ion Mobility Mass Spectrometry of the products of oligomerization of activated nucleotides with Montmorillonite
Presented at the American Society for Mass Spectrometry Annual Conference, Denver, CO.
Event: American Society for Mass Spectrometry Annual Conference at Denver, CO
Source: NC State University Libraries
Added: March 12, 2022
Employment
Updated: August 3rd, 2023 09:05
2017 - present
North Carolina State University Raleigh, NC, US
Senior Research Scholar/Research Assistant Professor
METRIC/Department of Biological Sciences
2016 - 2017
ScitoVation Research Triangle Park, NC, US
Associate Investigator
2012 - 2016
Ameritox Ltd Baltimore, MD, US
Principal Research Scientist
Research and Development
Education
Updated: July 18th, 2019 10:11
2007 - 2012
Vanderbilt University Nashville, TN, US
PhD
Chemistry
2002 - 2007
Drexel University Philadelphia, PA, US
B.S./M.S.
Chemistry
Funding History
Funding history based on the linked ORCID record. Updated: August 3rd, 2023 10:05
grant
November 1, 2022 - October 1, 2023
Assessment of Absorption and Distribution of Methyl Salicylate Following Skin Exposure in Human Subjects
Countering Weapons of Mass Destruction (CWMD) Consortium
grant
November 1, 2021 - December 1, 2022
Isomer Level Identification and Quantification of N-Linked Glycans by LC-SLIM-QTOF-MS
National Institute for Innovation in Manufacturing Biopharmaceuticals
grant
November 1, 2018 - October 1, 2023
Integrative Methods to Investigate The Role of Cyanotoxic Mixtures in Sporadic ALS
National Institutes of Health
grant
July 1, 2018 - June 1, 2019
Metabolomic and proteomic investigation of human exposure to GenX and PFAS compounds
National Institutes of Health
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