@article{ranck_linder_haber_meuten_2008, title={Primary intimal aortic angiosarcoma in a dog}, volume={45}, ISSN={["0300-9858"]}, DOI={10.1354/vp.45-3-361}, abstractNote={ A primary intimal aortic angiosarcoma was diagnosed in a 4-year-old, spayed female German Shepherd that presented for complications of thromboembolic disease because of infarcts in multiple organs. On gross examination, aneurysmal dilatation of the aorta was associated with a friable, necrotic mass attached to the endothelial surface, which partially occluded the aortic lumen. On histologic examination, plump neoplastic spindle cells formed a plaque-like mass arising from the intima that merged with a large accumulation of fibrin and necrotic debris, and projected into the lumen. Neoplastic cells invaded periaortic vessels and were seen in some infarct-associated thromboemboli. Tumor cells expressed vimentin and CD31, with infrequent, patchy staining with factor VIII-related antigen; tumor cells were negative for cytokeratin and smooth-muscle actin. Aortic angiosarcoma is a rare malignancy in humans. This is the first description of a primary intimal aortic angiosarcoma in a dog, with immunohistochemical evidence of endothelial origin. }, number={3}, journal={VETERINARY PATHOLOGY}, author={Ranck, R. S. and Linder, K. E. and Haber, M. D. and Meuten, D. J.}, year={2008}, month={May}, pages={361–364} }