Catherine S. Reed

Works (5)

Updated: July 5th, 2023 15:53

2012 journal article

Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae

ACS MEDICINAL CHEMISTRY LETTERS, 3(5), 357–361.

By: R. Worthington n, C. Bunders n, C. Reed n & C. Melander n

author keywords: NDM-1; Klebsiella pneumoniae; antibiotic adjuvant; resistance suppression; 2-aminoimidazole
TL;DR: A 2-aminoimidazole derived small molecule is identified that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae, able to lower carbapenem minimum inhibitory concentrations by up to 16-fold while exhibiting little bactericidal activity itself. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Modulating the development of E. coli biofilms with 2-aminoimidazoles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(21), 6310–6312.

By: C. Reed n, R. Huigens n, S. Rogers n & C. Melander n

author keywords: 2-Aminoimidazoles; E. coli; Biofilms
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Drug Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Hemolysis / drug effects; Humans; Imidazoles / chemical synthesis; Imidazoles / pharmacology; In Vitro Techniques; Structure-Activity Relationship
TL;DR: The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported, with the best inhibitor inhibiting biofilm development with an IC(50) of 13μM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation

JOURNAL OF ORGANIC CHEMISTRY, 74(4), 1755–1758.

By: T. Ballard  n, J. Richards n, A. Aquino  n, C. Reed n & C. Melander n

MeSH headings : Acylation; Biofilms / drug effects; Oxidation-Reduction; Proteobacteria / drug effects; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
TL;DR: This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

BIOORGANIC & MEDICINAL CHEMISTRY, 18(2), 663–674.

By: R. Huigens n, S. Reyes n, C. Reed n, C. Bunders n, S. Rogers n, A. Steinhauer n, C. Melander n

author keywords: 2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Resistance, Multiple, Bacterial; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Conformation; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
TL;DR: These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(15), 4325–4327.

By: J. Richards n, C. Reed n & C. Melander n

author keywords: biofilm; inhibition; dispersion; marine natural products; oroidin
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Humans; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
TL;DR: This work presents the anti-biofilm activity of a small library of second generation oroidin analogues against the bacterium Acinetobacter baumannii. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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