Works (5)
Updated: July 5th, 2023 16:03
2003 journal article
Metals mimic airway epithelial injury induced by in vitro exposure to Utah Valley ambient particulate matter extracts
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 66(12), 1087–1112.
MeSH headings : Air Pollutants, Occupational / isolation & purification; Air Pollutants, Occupational / toxicity; Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Male; Metals, Heavy / isolation & purification; Metals, Heavy / toxicity; Rats; Rats, Sprague-Dawley; Trachea / diagnostic imaging; Trachea / drug effects; Ultrasonography; Utah
TL;DR:
The parallel epithelial injury induced by the extracts and their surrogate Zn+Cu+V mixtures suggests that these metals are mediating the acute airway and respiratory health effects observed; however, metal interactions appear to play a critical role in the overall cellular effectsinduced by the PM-derived extracts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Effect of growth factor-fibronectin matrix interaction on rat type II cell adhesion and DNA synthesis
EXPERIMENTAL LUNG RESEARCH, 28(2), 69–84.
author keywords: alveolar repair; beta 1integrin; cell-substratum interaction; cytoskeleton; fibroblast growth factors; fibronectin; type II cells
MeSH headings : Actins / metabolism; Animals; Blood Proteins / pharmacology; Cell Adhesion / drug effects; Cell Division / drug effects; Cell Size / drug effects; Cells, Cultured; Cytoskeletal Proteins / metabolism; DNA / biosynthesis; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Fibronectins / pharmacology; Integrin beta1 / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR:
Together FGF-1 and fibronectin appear to promote adhesion, cytoskeletal organization, and in creased DNA synthesis, andin this way influence cell-substratum interactions and signaling during alveolar repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
TGF-beta 1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 279(6), L1038–L1046.
author keywords: basic fibroblast growth factor; acidic fibroblast growth factor; alveolar epithelium; alveolar injury; pulmonary fibrosis; transforming growth factor
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Fibrosis / metabolism; RNA, Messenger / analysis; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / genetics; Specific Pathogen-Free Organisms; Transforming Growth Factor beta / pharmacology
TL;DR:
Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factors (TGF)-β1, an important inflammatory cytokine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Sulfation of extracellular matrices modifies growth factor effects on type II cells on laminin substrata
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 275(4), L701–L708.
author keywords: sulfated proteoglycans; basement membrane; acidic fibroblast growth factor; basic fibroblast growth factor; keratinocyte growth factor
MeSH headings : Animals; Cell Adhesion / drug effects; Cell Division / drug effects; Cells, Cultured; Chondroitin / pharmacology; Chondroitin Sulfates / pharmacology; Chondroitin Sulfates / physiology; Extracellular Matrix / physiology; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2 / pharmacology; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances / pharmacology; Growth Substances / physiology; Heparin / pharmacology; Heparin / physiology; Heparitin Sulfate / pharmacology; Heparitin Sulfate / physiology; Laminin / pharmacology; Laminin / physiology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344
TL;DR:
It is demonstrated that decreased levels of sulfate in ECM substrata act to upregulate responses to heparin-binding growth factors by alveolar epithelial cells on laminin substrata.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Interleukin-1 beta increases prostaglandin E(2)-stimulated adenosine 3',5'-cyclic monophosphate production in rabbit pigmented ciliary epithelium
EXPERIMENTAL EYE RESEARCH, 63(1), 91–104.
author keywords: ciliary epithelium; cyclic AMP, interleukin-1; prostaglandins; transforming growth factor-beta; pigmented ciliary epithelium
MeSH headings : Animals; Cells, Cultured; Colforsin / pharmacology; Cyclic AMP / biosynthesis; Cycloheximide / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / pharmacology; Dose-Response Relationship, Drug; Indomethacin / pharmacology; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Kinetics; Lipopolysaccharides / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / metabolism; Protein Synthesis Inhibitors / pharmacology; Rabbits; Stimulation, Chemical; Transforming Growth Factor beta / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation; Vasoactive Intestinal Peptide / pharmacology
TL;DR:
This is the first report of prostaglandin E2-induced stimulation of adenosine 3',5'-cyclic monophosphate production by pigmented ciliary epithelial cells and of the unique ability of interleukin-1 to increase this effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018