Lori G. Rochelle

Works (4)

Updated: July 5th, 2023 16:04

1999 article

Tumor Necrosis Factor-α Stimulates Mucin Secretion and Cyclic GMP Production by Guinea Pig Tracheal Epithelial Cells In Vitro

Fischer, B. M., Rochelle, L. G., Voynow, J. A., Akley, N. J., & Adler, K. B. (1999, March 1). American Journal of Respiratory Cell and Molecular Biology.

By: B. Fischer n, L. Rochelle n, J. Voynow  n, N. Akley n & K. Adler n

MeSH headings : Animals; Cyclic GMP / biosynthesis; Cyclic GMP-Dependent Protein Kinases; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / immunology; Female; Guanylate Cyclase / metabolism; Guinea Pigs; Male; Models, Biological; Mucins / metabolism; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / metabolism; Protein Kinase C / antagonists & inhibitors; Protein Kinases / metabolism; Signal Transduction; Trachea / cytology; Trachea / drug effects; Trachea / immunology; Tumor Necrosis Factor-alpha / pharmacology; Type C Phospholipases / antagonists & inhibitors
topics (OpenAlex): Neonatal Respiratory Health Research; Cystic Fibrosis Research Advances; Asthma and respiratory diseases
TL;DR: The results suggest that TNF-alpha stimulates secretion of mucin by GPTE cells via a mechanism(s) dependent on PC-PLC and PKC, and involving activation of NOS, generation of NO, production of cGMP, and activation of PKG. (via Semantic Scholar)
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Added: August 6, 2018

1998 article

Concurrent Production of Reactive Oxygen and Nitrogen Species by Airway Epithelial Cells In Vitro

Rochelle, L. G., Fischer, B. M., & Adler, K. B. (1998, March 1). Free Radical Biology and Medicine.

By: L. Rochelle*, B. Fischer n & K. Adler n

author keywords: oxygen radicals; nitric oxide; airway epithelium; free radical
MeSH headings : Animals; Cell Line; Enzyme Activation; Epithelial Cells / metabolism; Free Radicals; Guinea Pigs; Macrophages / metabolism; Mice; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen / metabolism; Oxidative Stress / physiology; Reactive Oxygen Species / metabolism; Trachea / cytology; Trachea / metabolism
topics (OpenAlex): Nitric Oxide and Endothelin Effects; Neuroscience of respiration and sleep; Asthma and respiratory diseases
TL;DR: Both ROS and RNS can be measured in the same lysates from airway epithelial cells, and that both ROS andRNS are produced in these cells in response to different stimuli. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators

Martin, L. D., Rochelle, L. G., Fischer, B. M., Krunkosky, T. M., & Adler, K. B. (1997, September 1). European Respiratory Journal.

By: L. Martin*, L. Rochelle n, B. Fischer n, T. Krunkosky n & K. Adler n

author keywords: airway; cytokines; eicosanoids; epithelium; inflammation; reactive oxygen/nitrogen species
MeSH headings : Animals; Cytokines / metabolism; Epithelium / metabolism; Humans; Inflammation / metabolism; Inflammation / physiopathology; Inflammation Mediators / metabolism; Lipid Metabolism; Reactive Oxygen Species / metabolism; Respiratory System / metabolism; Respiratory System / pathology
topics (OpenAlex): Asthma and respiratory diseases; Pediatric health and respiratory diseases; Neonatal Respiratory Health Research
TL;DR: The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases, and molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleUKin-8 ( IL-8) are discussed. (via Semantic Scholar)
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1997 article

The Role of Reactive Oxygen and Nitrogen Species in the Response of Airway Epithelium to Particulates

Martin, L. D., Krunkosky, T. M., Dye, J. A., Fischer, B. M., Jiang, N. F., Rochelle, L. G., … Adler, K. B. (1997, September 1). Environmental Health Perspectives.

By: L. Martin n, T. Krunkosky n, J. Dye  n, B. Fischer n, N. Jiang  n, L. Rochelle n, N. Akley n, K. Dreher n, K. Adler n

author keywords: reactive oxygen/nitrogen species; signal transduction; airway inflammation; mucin hypersecretion; ICAM-1; TNF-alpha
topics (OpenAlex): Air Quality and Health Impacts; Inhalation and Respiratory Drug Delivery
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Added: August 6, 2018

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