Lori G. Rochelle

Works (4)

Updated: July 5th, 2023 16:04

1999 article

Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro

Fischer, B. M., Rochelle, L. G., Voynow, J. A., Akley, N. J., & Adler, K. B. (1999, March). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 20, pp. 413–422.

By: B. Fischer n, L. Rochelle n, J. Voynow  n, N. Akley n & K. Adler n

MeSH headings : Animals; Cyclic GMP / biosynthesis; Cyclic GMP-Dependent Protein Kinases; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / immunology; Female; Guanylate Cyclase / metabolism; Guinea Pigs; Male; Models, Biological; Mucins / metabolism; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / metabolism; Protein Kinase C / antagonists & inhibitors; Protein Kinases / metabolism; Signal Transduction; Trachea / cytology; Trachea / drug effects; Trachea / immunology; Tumor Necrosis Factor-alpha / pharmacology; Type C Phospholipases / antagonists & inhibitors
TL;DR: The results suggest that TNF-alpha stimulates secretion of mucin by GPTE cells via a mechanism(s) dependent on PC-PLC and PKC, and involving activation of NOS, generation of NO, production of cGMP, and activation of PKG. (via Semantic Scholar)
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1998 journal article

Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro

FREE RADICAL BIOLOGY AND MEDICINE, 24(5), 863–868.

By: L. Rochelle*, B. Fischer n & K. Adler n

author keywords: oxygen radicals; nitric oxide; airway epithelium; free radical
MeSH headings : Animals; Cell Line; Enzyme Activation; Epithelial Cells / metabolism; Free Radicals; Guinea Pigs; Macrophages / metabolism; Mice; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen / metabolism; Oxidative Stress / physiology; Reactive Oxygen Species / metabolism; Trachea / cytology; Trachea / metabolism
TL;DR: Both ROS and RNS can be measured in the same lysates from airway epithelial cells, and that both ROS andRNS are produced in these cells in response to different stimuli. (via Semantic Scholar)
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1997 review

Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators

[Review of ]. EUROPEAN RESPIRATORY JOURNAL, 10(9), 2139–2146.

By: L. Martin n, L. Rochelle n, B. Fischer n, T. Krunkosky n & K. Adler n

author keywords: airway; cytokines; eicosanoids; epithelium; inflammation; reactive oxygen/nitrogen species
MeSH headings : Animals; Cytokines / metabolism; Epithelium / metabolism; Humans; Inflammation / metabolism; Inflammation / physiopathology; Inflammation Mediators / metabolism; Lipid Metabolism; Reactive Oxygen Species / metabolism; Respiratory System / metabolism; Respiratory System / pathology
TL;DR: The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases, and molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleUKin-8 ( IL-8) are discussed. (via Semantic Scholar)
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1997 article

The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates

Martin, L. D., Krunkosky, T. M., Dye, J. A., Fischer, B. M., Jiang, N. F., Rochelle, L. G., … Adler, K. B. (1997, September). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 105, pp. 1301–1307.

By: L. Martin n, T. Krunkosky n, J. Dye  n, B. Fischer n, N. Jiang n, L. Rochelle n, N. Akley n, K. Dreher n, K. Adler n

author keywords: reactive oxygen/nitrogen species; signal transduction; airway inflammation; mucin hypersecretion; ICAM-1; TNF-alpha
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