Guadalupe Rojas

Works (1)

Updated: July 5th, 2023 16:04

1997 journal article

Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa

NATURE BIOTECHNOLOGY, 15(10), 965–970.

By: R. Petters n, C. Alexander n, K. Wells n, E. Collins n, . Sommer n, M. Blanton n, G. Rojas n, Y. Hao* ...

author keywords: transgenic swine; retinal degeneration; rhodopsin mutation; night blindness; eye disease
MeSH headings : Animals; Animals, Genetically Modified; Blotting, Southern; Disease Models, Animal; Electroretinography; Embryo Transfer; Gene Expression Regulation / genetics; Genetic Engineering; Microscopy, Electron; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Retina / pathology; Retina / physiopathology; Retina / ultrastructure; Retinal Cone Photoreceptor Cells / physiopathology; Retinal Cone Photoreceptor Cells / ultrastructure; Retinal Degeneration / physiopathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / chemistry; Rhodopsin / genetics; Swine / embryology; Swine / genetics; Transgenes
TL;DR: These transgenic pigs that express a mutated rhodopsin gene will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.