Works (1)
Updated: July 5th, 2023 16:04
1997 article
Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
Petters, R. M., Alexander, C. A., Wells, K. D., Collins, E. B., Sommer, J. R., Blanton, M. R., … Wong, F. (1997, October 1). Nature Biotechnology, Vol. 15, pp. 965–970.
author keywords: transgenic swine; retinal degeneration; rhodopsin mutation; night blindness; eye disease
MeSH headings : Animals; Animals, Genetically Modified; Blotting, Southern; Disease Models, Animal; Electroretinography; Embryo Transfer; Gene Expression Regulation / genetics; Genetic Engineering; Microscopy, Electron; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Retina / pathology; Retina / physiopathology; Retina / ultrastructure; Retinal Cone Photoreceptor Cells / physiopathology; Retinal Cone Photoreceptor Cells / ultrastructure; Retinal Degeneration / physiopathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / chemistry; Rhodopsin / genetics; Swine / embryology; Swine / genetics; Transgenes
topics (OpenAlex): Retinal Development and Disorders; Animal Genetics and Reproduction; CRISPR and Genetic Engineering
TL;DR:
These transgenic pigs that express a mutated rhodopsin gene will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018