Randy L. Rose

Works (42)

Updated: July 5th, 2023 16:04
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2010 journal article

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor

Toxicology and Applied Pharmacology, 245(3), 335–343.

By: R. Casabar, P. Das, G. DeKrey, C. Gardiner, Y. Cao, R. Rose, A. Wallace

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Metabolic interactions of agrochemicals in humans

Hodgson, E., & Rose, R. L. (2008, June). PEST MANAGEMENT SCIENCE, Vol. 64, pp. 617–621.

By: E. Hodgson n & R. Rose n

author keywords: cytochrome P450; environmental chemicals; hepatocytes; human metabolism; organophosphorus chemicals; risk assessment
MeSH headings : Drug Interactions; Environmental Pollutants / metabolism; Humans; Insecticides / metabolism; Microsomes, Liver / enzymology
Source: Web Of Science
Added: August 6, 2018

2007 article

Human metabolic interactions of environmental chemicals

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, Vol. 21, pp. 182–186.

By: E. Hodgson n & R. Rose n

author keywords: carbaryl; chlorpyrifos; chlorpyrifos oxon; cytochrome P450 (CYP); DEET; Endosulfan; environmental chemicals; estradiol; fipronil; Hepatocytes; human metabolism; naphthalene; nonane; organophosphorus chemicals; permethrin; pyrethroids; testosterone
MeSH headings : Cholinesterase Inhibitors / metabolism; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Enzyme Induction; Estradiol / metabolism; Female; Humans; Isoenzymes / metabolism; Liver / cytology; Liver / enzymology; Male; Microsomes, Liver / enzymology; Pesticides / metabolism; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / metabolism; Testosterone / antagonists & inhibitors; Testosterone / metabolism
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 21(2), 76–80.

By: H. Joo n, K. Choi n, R. Rose n & E. Hodgson n

author keywords: fipronil; nonane; human liver microsomes; cytochrome P450; CYP2B6; CYP3A4
MeSH headings : Alkanes / pharmacology; Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation / drug effects; Female; Humans; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Pyrazoles / pharmacology
Source: Web Of Science
Added: August 6, 2018

2007 review

The importance of cytochrome P4502B6 in the human metabolism of environmental chemicals

[Review of ]. PHARMACOLOGY & THERAPEUTICS, 113(2), 420–428.

By: E. Hodgson n & R. Rose n

author keywords: agrochemicals; cytochrome p450; cytochrome p450 2B6; environmental chemicals; induction; industrial chemicals; inhibition; metabolism; polymorphisms; xenobiotics
MeSH headings : Agrochemicals / metabolism; Aryl Hydrocarbon Hydroxylases / metabolism; Cytochrome P-450 CYP2B6; Environmental Pollutants / metabolism; Humans; Oxidoreductases, N-Demethylating / metabolism; Xenobiotics / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 article

Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes

Das, P. C., Cao, Y., Cherrington, N., Hodgson, E., & Rose, R. L. (2006, December 15). CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 164, pp. 200–214.

By: P. Das n, Y. Cao n, N. Cherrington *, E. Hodgson n & R. Rose n

author keywords: fipronil; human hepatic and HepG2 cells; CYP3A4; CYP2B6; CYP1A1; cytotoxicity; apoptosis
MeSH headings : Caspase 3 / metabolism; Caspase 7 / metabolism; Cell Survival / drug effects; Cells, Cultured; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Induction / drug effects; Gene Expression Regulation; Hepatocytes / drug effects; Hepatocytes / enzymology; Humans; Isoenzymes / genetics; Isoenzymes / metabolism; Pyrazoles / chemistry; Pyrazoles / pharmacology; RNA, Messenger / genetics; Sulfur / chemistry; Transcription, Genetic / genetics; fas Receptor / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 article

In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes

Cho, T. M., Rose, R. L., & Hodgson, E. (2006, January). DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 176–183.

By: T. Cho n, R. Rose* & E. Hodgson*

MeSH headings : Cytochrome P-450 Enzyme System / metabolism; Humans; Isoenzymes / metabolism; Kinetics; Microsomes, Liver / chemistry; Microsomes, Liver / metabolism; Molecular Structure; Naphthalenes / chemistry; Naphthalenes / metabolism; Naphthalenes / pharmacokinetics; Naphthoquinones / chemistry; Naphthoquinones / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 article

Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals

Usmani, K. A., Cho, T. M., Rose, R. L., & Hodgson, E. (2006, September). DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 1606–1614.

By: K. Usmani*, T. Cho, R. Rose* & E. Hodgson n

MeSH headings : Carbaryl / toxicity; Chlorpyrifos / toxicity; Cholinesterase Inhibitors / toxicity; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 CYP1A2 / metabolism; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / metabolism; Female; Fonofos / toxicity; Humans; In Vitro Techniques; Kinetics; Liver / drug effects; Liver / enzymology; Male; Microsomes, Liver; Military Medicine; Recombinant Proteins / antagonists & inhibitors; Recombinant Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes

Journal of Biochemical and Molecular Toxicology, 20(6), 279–291.

By: K. Choi n, H. Joo n, R. Rose n & E. Hodgson n

MeSH headings : Adult; Biotransformation; Chlorpyrifos / analogs & derivatives; Chlorpyrifos / analysis; Chlorpyrifos / chemistry; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Chromatography, High Pressure Liquid; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Male; Mass Spectrometry; Middle Aged; Subcellular Fractions
Source: NC State University Libraries
Added: August 6, 2018

2006 article

Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4

Casabar, R. C. T., Wallace, A. D., Hodgson, E., & Rose, R. L. (2006, October). DRUG METABOLISM AND DISPOSITION, Vol. 34, pp. 1779–1785.

By: R. Casabar, A. Wallace, E. Hodgson* & R. Rose*

MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Biotransformation / drug effects; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Endosulfan / chemistry; Endosulfan / metabolism; Endosulfan / pharmacokinetics; Enzyme Inhibitors / pharmacology; Humans; Insecticides / chemistry; Insecticides / metabolism; Insecticides / pharmacokinetics; Ketoconazole / pharmacology; Kinetics; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Microsomes, Liver / metabolism; Molecular Structure; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Oxygenases / metabolism; Steroid Hydroxylases / metabolism; Sulfates / metabolism; Ticlopidine / pharmacology
Source: Web Of Science
Added: August 6, 2018

2006 review

Organophosphorus chemicals: Potent inhibitors of the human metabolism of steroid hormones and xenobiotics

[Review of ]. DRUG METABOLISM REVIEWS, 38(1-2), 149–162.

By: E. Hodgson n & R. Rose n

author keywords: carbaryl; chlorpyrifos; chlorpyrifos oxon; cytochrome P450 (CYP); DEET; estradiol; human CYP isoforms; human liver microsomes; organophosphorus insecticides; permethrin; testosterone
MeSH headings : Animals; Carbaryl / metabolism; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; DEET / metabolism; Depression, Chemical; Estrogens / metabolism; Female; Humans; Insect Repellents / metabolism; Insecticides / metabolism; Insecticides / pharmacology; Male; Organophosphorus Compounds / pharmacology; Steroids / metabolism; Testosterone / metabolism; Xenobiotics / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 review

Human metabolism and metabolic interactions of deployment-related chemicals

[Review of ]. DRUG METABOLISM REVIEWS, 37(1), 1–39.

By: E. Hodgson n & R. Rose n

author keywords: alcohol dehydrogenase; aldehyde dehydrogenase; carbamates; chemical warfare agents; cytochrome P450; deployment-related chemicals; jet fuel components; metabolic interactions; metabolism; organophosphorus compounds; pyrethroids; repellents; xenobiotic-metabolizing enzymes
MeSH headings : Drug Interactions; Humans; Inactivation, Metabolic; Military Medicine; Xenobiotics / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pesticide metabolism and potential for metabolic interactions

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(4), 276–277.

By: R. Rose n & E. Hodgson n

MeSH headings : Agriculture; Cytochrome P-450 Enzyme System / drug effects; Cytochrome P-450 Enzyme System / metabolism; Humans; Microsomes, Liver / enzymology; Occupational Exposure; Pesticides / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pesticide metabolism in humans, including polymorphisms

Scandinavian Journal of Work, Environment & Health, 31, 156–163.

By: R. Rose, J. Tang, J. Choi, Y. Cao, A. Usmani, N. Cherrington, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

The metabolism of nonane, a JP-8 jet fuel component, by human liver microsomes, P450 isoforms and alcohol dehydrogenase and inhibition of human P450 isoforms by JP-8

CHEMICO-BIOLOGICAL INTERACTIONS, 151(3), 203–211.

By: J. Edwards n, R. Rose n & E. Hodgson n

author keywords: nonane; JP-8; metabolism; cytochrome P450; alcohol dehydrogenase
MeSH headings : Alcohol Dehydrogenase / metabolism; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; DEET / pharmacokinetics; Estradiol / metabolism; Fossil Fuels; Humans; Hydrocarbons / pharmacokinetics; Hydrocarbons / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Testosterone / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Toxicology of AHS important chemicals

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 19(3), 180–181.

By: E. Hodgson n & R. Rose n

MeSH headings : Agriculture; Animals; Health Surveys; Humans; Insecticides / toxicity; Pesticides / toxicity
Source: Web Of Science
Added: August 6, 2018

2004 journal article

In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol

CHEMICO-BIOLOGICAL INTERACTIONS, 150(3), 221–232.

By: K. Usmani n, E. Hodgson n & R. Rose n

author keywords: carbofuran; metabolism; human liver microsomes; cytochrome P450; CYP3MA4; testosterone; interactions
MeSH headings : Animals; Carbofuran / metabolism; Carbofuran / pharmacology; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / metabolism; Drug Interactions / physiology; Estradiol / metabolism; Estradiol / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Ketoconazole / pharmacology; Liver / cytology; Liver / enzymology; Mice; Microsomes, Liver / enzymology; Pesticides / metabolism; Rats; Testosterone / metabolism; Testosterone / pharmacology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam

CHEMICO-BIOLOGICAL INTERACTIONS, 147(3), 319–329.

By: J. Tang n, K. Usmani n, E. Hodgson n & R. Rose n

author keywords: fipronil; metabolism; human liver microsomes; cytochrome p450; CYP3A4; interaction
MeSH headings : Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / metabolism; Diazepam / metabolism; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors / pharmacology; Humans; Insecticides / metabolism; Isoenzymes / metabolism; Ketoconazole / pharmacology; Microsomes, Liver / enzymology; Pyrazoles / metabolism; Rats; Species Specificity; Testosterone / metabolism
Source: Web Of Science
Added: August 6, 2018

2004 journal article

In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily

DRUG METABOLISM AND DISPOSITION, 32(3), 333–339.

By: K. Usmani n, E. Karoly*, E. Hodgson* & R. Rose*

MeSH headings : Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System / metabolism; Enzyme Inhibitors / pharmacology; Humans; In Vitro Techniques; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Mixed Function Oxygenases / antagonists & inhibitors; Monoamine Oxidase / metabolism; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfaphenazole / pharmacology; Sulfides / metabolism; Sulfoxides / metabolism; Ticlopidine / pharmacology
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals

DRUG METABOLISM AND DISPOSITION, 31(4), 384–391.

By: K. Usmani n, R. Rose* & E. Hodgson*

MeSH headings : Chlorpyrifos / pharmacology; Cholinesterase Inhibitors / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Gonadal Steroid Hormones / metabolism; Humans; In Vitro Techniques; Isoenzymes / metabolism; Kinetics; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Steroid Hydroxylases / metabolism; Testosterone / metabolism
Source: Web Of Science
Added: August 6, 2018

2002 journal article

In vitro human metabolism and interactions of repellent N,N-diethyl-M-toluamide

DRUG METABOLISM AND DISPOSITION, 30(3), 289–294.

By: K. Usmani n, R. Rose*, J. Goldstein*, W. Taylor, A. Brimfield & E. Hodgson*

MeSH headings : Animals; Biotransformation; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DEET / analogs & derivatives; DEET / metabolism; DEET / pharmacokinetics; Drug Interactions; Enzyme Induction / drug effects; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Female; Humans; In Vitro Techniques; Insect Repellents / metabolism; Insect Repellents / pharmacokinetics; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Oxidation-Reduction; Permethrin / metabolism; Permethrin / pharmacology; Pyridostigmine Bromide / metabolism; Pyridostigmine Bromide / pharmacology; Rats; Rats, Long-Evans; Spectrometry, Fluorescence
Source: Web Of Science
Added: August 6, 2018

2002 journal article

In vitro human metabolism of permethrin: the role of human alcohol and aldehyde dehydrogenases

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 74(3), 117–128.

By: J. Choi n, R. Rose n & E. Hodgson n

author keywords: permethrin; permethrin metabolism; human alcohol dehydrogenase; human aldehyde dehydrogenase
Source: Web Of Science
Added: August 6, 2018

2002 journal article

In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos

CHEMICO-BIOLOGICAL INTERACTIONS, 141(3), 229–241.

By: J. Tang n, Y. Cao n, R. Rose n & E. Hodgson n

author keywords: carbaryl; human lifer microsomes; metabolism
MeSH headings : Adult; Carbaryl / metabolism; Cells, Cultured; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation / drug effects; Insecticides / metabolism; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Kinetics; Male; Microsomes, Liver; Molecular Structure
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Cloning, sequencing, heterologous expression, and ch;characterization of murine cytochrome p450 3a25*(Cyp3a25), a testosterone 6 beta-hydroxylase

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 15(2), 90–99.

By: D. Dai*, R. Bai n, E. Hodgson n & R. Rose n

author keywords: Cyp3a-25; cloning; sequencing; heterologous expression; metabolism and distribution; testosterone 6 beta-hydroxylase
MeSH headings : Aging; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Northern; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Escherichia coli / genetics; Female; Immunoblotting; Isoenzymes / genetics; Male; Mice; Molecular Sequence Data; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics; Pregnancy; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Tissue Distribution; Transfection
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos

Journal of Pharmacology and Experimental Therapeutics, 299(3), 825–831.

By: D. Dai, J. Tang, R. Rose, E. Hodgson, R. Bienstock, H. Mohrenweiser, J. Goldstein

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes

Drug Metabolism and Disposition, 29(9), 1201–1204.

By: J. Tang, Y. Cao, R. Rose, A. Brimfield, D. Dai, J. Goldstein, E. Hodgson

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene, vinclozolin, and flutamide

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 70(3), 127–141.

By: D. Dai*, Y. Cao n, G. Falls*, P. Levi n, E. Hodgson n & R. Rose n

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 15(6), 300–308.

By: E. Karoly n & R. Rose n

author keywords: FMO2; sequence; characterization; expression; mouse
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Catalysis; Cloning, Molecular; DNA, Complementary; Escherichia coli / genetics; Expressed Sequence Tags; Humans; Mice; Molecular Sequence Data; NADP / metabolism; Oxidation-Reduction; Oxygenases / chemistry; Oxygenases / genetics; Oxygenases / metabolism; Sequence Homology, Amino Acid; Substrate Specificity
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes.

ENVIRONMENTAL HEALTH PERSPECTIVES, 108(12), 1151–1157.

By: S. Coleman*, R. Linderman*, E. Hodgson* & R. Rose*

author keywords: chloroacetamide herbicides; human cytochrome P450; in vitro metabolism
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Detection of resistant insects and IPM

Emerging Technologies for Integrated Pest Management : Concepts, Research, and Implementation, 67.

By: R. Roe , W. Bailey, F. Gould, C. Sorenson, G. Kennedy, J. Bacheler, R. Rose, E. Hodgson, C. Sutula

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 14(2), 118–120.

By: E. Hodgson n, R. Rose n, Y. Cao n, S. Dehal* & D. Kupfer*

author keywords: flavin-containing monooxygenase; FMO; FMO isoforms; tamoxifen; human; mouse
Source: Web Of Science
Added: August 6, 2018

1999 article

In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms

Coleman, S., Liu, S. M., Linderman, R., Hodgson, E., & Rose, R. L. (1999, August 30). CHEMICO-BIOLOGICAL INTERACTIONS, Vol. 122, pp. 27–39.

By: S. Coleman n, S. Liu n, R. Linderman n, E. Hodgson n & R. Rose n

author keywords: alachlor; CDEPA; human CYP; herbicides
MeSH headings : Acetamides / metabolism; Animals; Cytochrome P-450 Enzyme System / metabolism; Female; Herbicides / metabolism; Humans; In Vitro Techniques; Isoenzymes / metabolism; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Rats; Rats, Long-Evans
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Metabolism of [C-14]prometryn in rats

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 47(9), 3858–3865.

By: M. Maynard n, D. Brumback n, W. Itterly n, T. Capps n & R. Rose n

author keywords: prometryn; metabolites; rats; in vivo; in vitro; cytochrome P-450; FMO
MeSH headings : Animals; Biotransformation; Carbon Radioisotopes; Female; Gas Chromatography-Mass Spectrometry; Male; Prometryne / blood; Prometryne / pharmacokinetics; Rats; Rats, Inbred Strains; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Basic principles and rationale for the use of insect genes in bioremediation: esterases, phosphotriesterase, cytochrome P450 and epoxide hydrolase

Reviews in Toxicology, 2(1998), 169–178.

By: R. Roe , E. Hodgson, R. Rose, D. Thompson, C. Devorshak, D. Anspaugh, R. Linderman, S. Harris, M. Tomalski

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Flavin-containing monooxygenase and cytochrome P450 mediated metabolism of pesticides: from mouse to human

Reviews in Toxicology, 2(1998), 231–243.

By: E. Hodgson, N. Cherrington, S. Coleman, S. Liu, J. Falls, Y. Cao, J. Goldstein, R. Rose

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)

Journal of Biochemical and Molecular Toxicology, 12(1998), 205–212.

By: N. Cherrington n, J. Falls n, R. Rose n, K. Clements n, R. Philpot*, P. Levi n, E. Hodgson n

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5

XENOBIOTICA, 28(7), 673–682.

By: N. Cherrington n, Y. Cao n, J. Cherrington n, R. Rose n & E. Hodgson n

MeSH headings : Adult; Animals; Female; Humans; Liver / embryology; Liver / metabolism; Male; Mice; Microsomes, Liver / metabolism; Middle Aged; Oxygenases / biosynthesis; Rats; Sex Characteristics; Species Specificity
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Cytochrome P450 (CYP)9A1 in Heliothis virescens: The first member of a new CYP family

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 27(6), 605–615.

By: R. Rose n, D. Goh n, D. Thompson n, K. Verma n, D. Heckel *, L. Gahan*, R. Roe n , E. Hodgson n

author keywords: CYP9A1; cytochrome P450; insecticide resistance; Heliothis virescens
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / isolation & purification; DNA, Complementary; Female; Insecticide Resistance; Male; Molecular Sequence Data; Moths / enzymology; Moths / genetics; Sequence Homology, Amino Acid
Sources: Web Of Science, ORCID
Added: August 6, 2018

1997 journal article

Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): Comparison with the human isoform

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 347(1), 9–18.

By: J. Falls n, N. Cherrington n, K. Clements n, R. Philpot *, P. Levi n, R. Rose n, E. Hodgson n

author keywords: flavin-containing monooxygenase 3; FMO3; FMO3 sequence; FMO3 expression
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Catalysis; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors / pharmacology; Enzyme Stability; Escherichia coli / genetics; Female; Gene Expression; Humans; Hydrogen-Ion Concentration; Liver / enzymology; Male; Methimazole / metabolism; Mice; Molecular Sequence Data; Oxygenases / chemistry; Oxygenases / genetics; Oxygenases / metabolism; RNA, Messenger / analysis; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Sequence Analysis, DNA; Sequence Homology, Amino Acid
Source: Web Of Science
Added: August 6, 2018

1996 patent

Insecticide resistance associated cytochrome 450

Washington, DC: U.S. Patent and Trademark Office.

By: R. Roe , E. Hodgson & R. Rose

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

CYTOCHROME P450-ASSOCIATED INSECTICIDE RESISTANCE AND THE DEVELOPMENT OF BIOCHEMICAL DIAGNOSTIC ASSAYS IN HELIOTHIS-VIRESCENS

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 51(3), 178–191.

By: R. Rose n, L. Barbhaiya n, R. Roe n, G. Rock n & E. Hodgson n

Source: Web Of Science
Added: August 6, 2018

1991 journal article

DIFFERENCES IN CYTOCHROME-P450 ACTIVITIES IN TOBACCO BUDWORM LARVAE AS INFLUENCED BY RESISTANCE TO HOST PLANT ALLELOCHEMICALS AND INDUCTION

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 99(3), 535–540.

By: R. Rose n, F. Gould  n, P. Levi n & E. Hodgson n

Source: Web Of Science
Added: August 6, 2018