Jonathan C. Swaffield

author keywords: proteasome; proteasomal ATPases; multiprotein complex; cross-linking; AAA ATPase; evolution

MeSH headings : Adenosine Triphosphatases / genetics; Adenosine Triphosphatases / metabolism; Animals; Archaea / enzymology; Archaea / genetics; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / metabolism; Eukaryotic Cells / enzymology; Eukaryotic Cells / metabolism; Evolution, Molecular; Humans; Models, Genetic; Multienzyme Complexes / genetics; Multienzyme Complexes / metabolism; Peptide Hydrolases / genetics; Peptide Hydrolases / metabolism; Phylogeny; Proteasome Endopeptidase Complex

topics (OpenAlex): Ubiquitin and proteasome pathways; Glycosylation and Glycoproteins Research; Peptidase Inhibition and Analysis

TL;DR: A model of a possible evolutionary history of the proteasomal ATPASES is constructed, incorporation of physical data to provide support for alternative phylogenetic hypotheses, and shows that the deep node structures of the phylogenetic constructions lack resolution. (via Semantic Scholar)

author keywords: AAA proteins; ATPase; proteasome; NSF; Sec; Pas; metalloprotease

MeSH headings : Adenosine Triphosphatases / classification; Adenosine Triphosphatases / metabolism; Adenosine Triphosphatases / physiology; Archaea / genetics; Bacteria / genetics; Cysteine Endopeptidases / metabolism; Cytoskeletal Proteins / metabolism; Cytoskeletal Proteins / physiology; Eukaryotic Cells / physiology; Evolution, Molecular; Membrane Proteins / metabolism; Membrane Proteins / physiology; Metalloendopeptidases / metabolism; Metalloendopeptidases / physiology; Multienzyme Complexes / metabolism; Phylogeny; Proteasome Endopeptidase Complex

topics (OpenAlex): Genomics and Phylogenetic Studies; Bacterial Genetics and Biotechnology; RNA and protein synthesis mechanisms

TL;DR: The phylogeny of the CADs provides the basis for establishing the patterns of evolutionary change that characterize the AAA proteins. (via Semantic Scholar)