John G. Vandenbergh
Works (33)
Updated: July 5th, 2023 16:04
2016 journal article
Twenty-five years of endocrine disruption science: Remembering Theo Colborn
Environmental Health Perspectives, 124(9), A151–154.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: The case of bisphenol A
Environmental Health Perspectives, 117(3), 309–315.
Source: NC State University Libraries
Added: August 6, 2018
2008 review
NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
[Review of ]. Birth Defects Research. Part B, Developmental and Reproductive Toxicology, 83(3), 157–395.
Source: NC State University Libraries
Added: August 6, 2018
2007 personal communication
Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
Source: NC State University Libraries
Added: August 6, 2018
2007 review
In vivo effects of bisphenol A in laboratory rodent studies
[Review of ]. Reproductive Toxicology (Elmsford, N.Y.), 24(2), 199–224.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Developmental exposure to environmental estrogens alters anxiety and spatial memory in female mice
HORMONES AND BEHAVIOR, 50(1), 85–93.
author keywords: endocrine disruptor; environmental estrogen; bisphenol A; ethinyl estradiol; anxiety; spatial memory; puberty; behavior; mouse
MeSH headings : Analysis of Variance; Animals; Anxiety / chemically induced; Benzhydryl Compounds; Dose-Response Relationship, Drug; Endocrine Disruptors / pharmacology; Environmental Pollutants / pharmacology; Ethinyl Estradiol / pharmacology; Exploratory Behavior / drug effects; Female; Maze Learning / drug effects; Mice; Mice, Inbred C57BL; Phenols / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects / physiopathology; Sex Characteristics; Sexual Maturation / drug effects; Space Perception / drug effects; Spatial Behavior / drug effects
TL;DR:
The results indicate that non-reproductive, sexually dimorphic behavior is sensitive to endocrine disruption and suggest that both humans and wildlife are being exposed to levels of these endocrine disrupting compounds that are sufficient to disrupt the development of the nervous system and that may have permanent consequences on sexuallyDimorphic behaviors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Prenatal testosterone exposure permanently masculinizes anogenital distance, nipple development, and reproductive tract morphology in female Sprague-Dawley rats
TOXICOLOGICAL SCIENCES, 96(2), 335–345.
author keywords: AGD; areola; masculinization; reproductive development; fetal androgen; intrauterine position
MeSH headings : Abnormalities, Drug-Induced / etiology; Abnormalities, Drug-Induced / pathology; Anal Canal / abnormalities; Anal Canal / drug effects; Animals; Animals, Newborn / abnormalities; Endocrine Disruptors / chemistry; Endocrine Disruptors / toxicity; Estrus / drug effects; Estrus / physiology; Female; Fetus / abnormalities; Fetus / drug effects; Genitalia, Female / abnormalities; Genitalia, Female / drug effects; Gestational Age; Male; Nipples / drug effects; Nipples / embryology; Nipples / growth & development; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Testosterone / chemistry; Testosterone / toxicity; Uterus / abnormalities; Uterus / drug effects; Vagina / abnormalities; Vagina / drug effects; Weight Loss / drug effects
TL;DR:
TP-induced changes in neonatal AGD and infant areola number were reliable indicators of permanently altered adult phenotype in female Rats, and females in the two high-dose groups displayed increased incidences of external genital malformations and the presence of prostatic tissue, not normally found in female rats.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole
NEUROTOXICOLOGY AND TERATOLOGY, 28(1), 103–110.
author keywords: pine vole; monogamy; endocrine disruption; oxytocin; DES; methoxychlor
MeSH headings : Aggression / drug effects; Animals; Animals, Newborn; Arvicolinae; Behavior, Animal / drug effects; Binding, Competitive / drug effects; Brain / drug effects; Brain / pathology; Brain / physiopathology; Diethylstilbestrol / toxicity; Disease Models, Animal; Estradiol Congeners / toxicity; Female; Gyrus Cinguli / drug effects; Gyrus Cinguli / metabolism; Methoxychlor / toxicity; Pair Bond; Pregnancy; Prenatal Exposure Delayed Effects / pathology; Prenatal Exposure Delayed Effects / physiopathology; Receptors, Oxytocin / drug effects; Receptors, Oxytocin / metabolism; Social Behavior
TL;DR:
It is demonstrated that exposure to EDCs during pre- and neonatal development can alter female adult neural phenotype and behavior related to monogamous behavior traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
The anogenital distance index of mice (Mus musculus domesticus): An analysis
Contemporary Topics in Laboratory Animal Science, 44(4), 46–48.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
A mixture of the "antiandrogens" linuron and butyl benzyl phthalate alters sexual differentiation of the male rat in a cumulative fashion
BIOLOGY OF REPRODUCTION, 71(6), 1852–1861.
author keywords: androgen receptor; male reproductive tract; male sexual function; testosterone; toxicology
MeSH headings : Anal Canal / anatomy & histology; Androgen Antagonists / administration & dosage; Androgen Antagonists / pharmacology; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Fetus / metabolism; Genitalia, Male / anatomy & histology; Genitalia, Male / embryology; Linuron / administration & dosage; Linuron / pharmacology; Male; Osmolar Concentration; Phthalic Acids / administration & dosage; Phthalic Acids / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects; Progesterone / metabolism; Rats; Rats, Sprague-Dawley; Sex Differentiation / drug effects; Testis / metabolism; Testosterone / metabolism
TL;DR:
Treatment-related changes to neonatal AGD and infant areolae significantly correlated with adult AGD, nipple retention, reproductive malformations, and reproductive organ and tissue weights provide additional evidence of cumulative effects of antiandrogen mixtures on male reproductive development.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Animal models and studies of in utero endocrine disruptor effects
ILAR JOURNAL, 45(4), 438–442.
author keywords: animal models; anogenital distance; endocrine disruptors; intrauterine position; prenatal; stress
MeSH headings : Animals; Animals, Laboratory; Endocrine Glands / drug effects; Endocrine Glands / embryology; Endocrine Glands / pathology; Female; Hormone Antagonists / toxicity; Maternal Exposure / adverse effects; Models, Animal; Pregnancy; Prenatal Exposure Delayed Effects; Toxicity Tests / methods
TL;DR:
In experimental studies, compounds that mimic estrogens and those that block androgen action have been shown to have a number of long-term effects, including acceleration of puberty onset, increased incidence of adult cancers, and alterations in sexually dimorphic anatomy, physiology, and behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
An environmental antiandrogen, vinclozolin, alters the organization of play behavior
PHYSIOLOGY & BEHAVIOR, 79(2), 151–156.
author keywords: vinclozolin; play; environmental
MeSH headings : Aging / psychology; Androgen Antagonists / pharmacology; Animals; Animals, Newborn / growth & development; Animals, Newborn / psychology; Behavior, Animal / drug effects; Female; Flutamide / pharmacology; Fungicides, Industrial / pharmacology; Interpersonal Relations; Male; Oxazoles / pharmacology; Play and Playthings; Rats; Rats, Sprague-Dawley
TL;DR:
Perinatal exposure to vinclozolin, an environmental antiandrogen, can alter androgen-dependent behavior, such as play, in the male rat, this study suggests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Prenatal hormone exposure and sexual variation
American Scientist, 91(3), 218–225.
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2003 chapter
Rickettsia rickettsii infection in the pine vole, Microtus pinetorum: Kinetics of infection and quantitation of antioxidant enzyme gene expression by RT-PCR
In Rickettsiology: Present and future directions (Vol. 990, pp. 468–473). New York, NY: New York Academy of Sciences.
Source: NC State University Libraries
Added: August 6, 2018
2002 article
Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat
Hotchkiss, A. K., Ostby, J. S., Vandenbergh, J. G., & Gray, L. E. (2002, June). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 110, pp. 435–439.
author keywords: androgens; anogenital distance; antiandrogens; endocrine-disrupting chemicals; intrauterine position; play behavior; reproductive development
MeSH headings : Androgen Antagonists / adverse effects; Androgens / pharmacology; Animals; Animals, Newborn; Environmental Exposure; Female; Gonads / growth & development; Male; Oxazoles / adverse effects; Play and Playthings; Rats; Rats, Sprague-Dawley; Reproduction; Risk Assessment; Social Behavior
TL;DR:
It is demonstrated that perinatal exposure to vinclozolin, an environmental antiandrogen, can alter androgen-dependent play behavior in the male rat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Impaired olfactory behavior in mice deficient in the a subunit of G(0)
BRAIN RESEARCH, 941(1-2), 62–71.
author keywords: G protein; knock-out mouse; olfaction; chemoreception; behavioral genetics; olfactory bulb
MeSH headings : Analysis of Variance; Animals; Behavior, Animal; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins / deficiency; Heterotrimeric GTP-Binding Proteins / genetics; Immunohistochemistry; Male; Mice; Mice, Knockout; Odorants; Olfactory Bulb / cytology; Olfactory Receptor Neurons; Phenotype; Smell / genetics
TL;DR:
Gαo is necessary for the expression of olfactory behavior under normal conditions and dependent on genetic background, but is not essential for the formation and maintenance of glomeruli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 review
Intrauterine position effects
[Review of ]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 26(6), 665–678.
author keywords: anogenital distance; behavior; endocrine disruption; human; intrauterine position; rodent; stress; testosterone; toxicology
MeSH headings : Aggression; Animals; Behavior, Animal; Embryonic and Fetal Development / physiology; Environment; Female; Gonadal Steroid Hormones / metabolism; Gonadal Steroid Hormones / pharmacology; Gonadal Steroid Hormones / physiology; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects; Sex Characteristics; Sex Differentiation / physiology; Sex Factors; Sex Ratio; Sexual Behavior; Stress, Physiological; Territoriality; Twin Studies as Topic; Uterus / embryology; Uterus / enzymology; Uterus / physiology
TL;DR:
IUP effects may impact a number of scientific fields of research such as endocrine disruption, toxicology, population biology, animal production and health, and some of these effects are similar to the influence of prenatal stress on adult phenotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 patent
Altering sex ratio of offspring in mammals
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2001 book
Exploring the biological contributions to human health: Does sex matter?
Washington, DC: National Academy Press.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice
American Journal of Physiology, 278(2 pt.2), R320–330.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Environmental toxins - Exposure to bisphenol A advances puberty
NATURE, 401(6755), 763–764.
MeSH headings : Animals; Benzhydryl Compounds; Body Weight / drug effects; Estrogens, Non-Steroidal / pharmacology; Female; Fetus / drug effects; Humans; Male; Mice; Models, Biological; Phenols / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects; Sexual Maturation / drug effects
TL;DR:
It is shown that exposing female mouse fetuses to an EEDC at a dose that is within the range typical of the environmental exposure of humans alters the postnatal growth rate and brings on early puberty in these mice.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Intrauterine position: IUP phenomenon
Encyclopedia of Reproduction, 2, 895–900.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Pheromones
Encyclopedia of Reproduction, 3, 764–770.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Puberty Acceleration
Encyclopedia of Reproduction, 4, 125–127.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Species, interindividual, and tissue specificity in endocrine signaling
Environmental Health Perspectives, 107(1999 Aug.), 619–624.
MeSH headings : Age Factors; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endocrine System / drug effects; Endocrine System / physiology; Environmental Pollutants / adverse effects; Humans; Menopause; Models, Theoretical; Receptors, Estrogen / drug effects; Receptors, Estrogen / physiology; Signal Transduction; Species Specificity; Transcription, Genetic; Xenobiotics / adverse effects
TL;DR:
The use of animal model systems and development of appropriate mathematical models has the potential to yield additional valuable information for elucidating the role of these determinants of specificity at low-dose exposures and for improved risk assessments for the adverse health effects of endocrine-active compounds.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Whitten effect
Encyclopedia of Reproduction, 4, 1020–1024.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Behavioural suppression of female pine voles after replacement of the breeding male
ANIMAL BEHAVIOUR, 55, 615–627.
TL;DR:
It is proposed that the mother's tugging on the daughter may lead to subordination of thedaughter, which could delay reproductive activation of the daughter, prevent the formation of pair bonds or inhibit sexual behaviour.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Social influences on intergroup transfer by pine voles (Microtus pinetorum)
CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE, 76(12), 2131–2136.
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Chronic cocaine exposure affects stimulus-induced but not spontaneous behavior of the near-term mouse fetus
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 58(3), 793–799.
author keywords: cocaine; fetus; behavior; gestation; prenatal
MeSH headings : Ammonia / pharmacology; Animals; Cocaine / pharmacology; Female; Fetal Movement / drug effects; Mice; Mice, Inbred ICR; Narcotics / pharmacology; Physical Stimulation; Pregnancy; Stimulation, Chemical; Umbilical Cord / physiology
TL;DR:
The results suggest that the mouse may be a viable model for studies of the neurodevelopmental effects of gestational cocaine exposure and are discussed in relation to current models of the effects of long-term cocaine exposure on brain neurochemistry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Using DNA fingerprinting to estimate relatedness within social groups of pine voles
JOURNAL OF MAMMALOGY, 78(3), 715–724.
author keywords: Microtus pinetorum; pine vole; DNA fingerprinting; cooperative breeding; rodent; microtine
TL;DR:
In two of the five groups, band-sharing values suggest that offspring from previous litters remain philopatric beyond weaning, while parents produce successive litters, which is consistent with a monogamous mating system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1989 journal article
Coordination of social signals and ovarian function during sexual development
Journal of Animal Science, 67(7), 1841.
Source: NC State University Libraries
Added: August 6, 2018
1988 journal article
Social interactions and the coordination of reproductive behavior in rodents and nonhuman primates
Journal of the American Veterinary Medical Association, 193(9), 1161.
Source: NC State University Libraries
Added: August 6, 2018
1983 chapter
Pheromonal regulation of puberty
In Pheromones and reproduction in mammals (p. 95). New York: Academic Press.
Source: NC State University Libraries
Added: August 6, 2018
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