G. A. Le Blanc

Works (4)

Updated: July 5th, 2023 15:53

2015 journal article

Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity

Environmental Toxicology and Chemistry, 34(9), 2013–2022.

By: E. Mihaich, S. Erler, G. Le Blanc & S. Gallagher

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex

BMC Genomics, 10.

By: S. Thomson, W. Baldwin, Y. Wang, G. Kwon & G. LeBlanc

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Interactions of methyl farnesoate and related compounds with a crustacean retinoid X receptor

Molecular and Cellular Endocrinology, 309(1-2), 109–116.

By: Y. Wang n & G. LeBlanc n 

author keywords: RXR; EcR; Methyl farnesoate; Daphnia; Tributyltin
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; DNA, Complementary / genetics; DNA, Complementary / isolation & purification; Daphnia / drug effects; Daphnia / metabolism; Ecdysterone / pharmacology; Fatty Acids, Unsaturated / metabolism; Genes, Reporter; Humans; Ligands; Luciferases / metabolism; Male; Molecular Sequence Data; Open Reading Frames / genetics; Receptors, Steroid / metabolism; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Retinoid X Receptors / metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Sex Determination Processes; Sex Ratio; Transcriptional Activation / drug effects
TL;DR: Results indicate that methyl farnesoate, along with compounds that are functionally similar to methyl farNESoate synergize with ecdysteroids to activate the RXR:EcR receptor complex, however, this effect appears to be unrelated to the ability of these compounds to stimulate male sex determination. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

1994 journal article

Effect of the plant compound indole-3-carbinol on hepatic cholesterol homoeostasis

Food and Chemical Toxicology, 32(7), 633–639.

By: G. Le Blanc n, J. Stuart n, S. Dunn n & W. Baldwin  n

MeSH headings : Animals; Cholesterol / blood; Cholesterol / chemistry; Cholesterol 7-alpha-Hydroxylase / metabolism; Homeostasis / drug effects; Indoles / pharmacology; Liver / chemistry; Liver / drug effects; Male; Mice; Microsomes, Liver / chemistry; Microsomes, Liver / drug effects; Sterol Esterase / metabolism; Sterol O-Acyltransferase / metabolism
TL;DR: I3C lowers serum cholesterol levels at concentrations that have no discernible effect on hepatic cholesterol homoeostasis, and at higher doses of I3C, hepatic microsomal cholesterol levels are significantly lowered and ACAT activity is significantly elevated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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