@article{ioannou_dauterman_1979, title={In vitro metabolism of diazinon and etrimfos by corn plant preparations}, volume={10}, DOI={10.1016/0048-3575(79)90024-5}, abstractNote={Homogenates prepared from excised roots or stems and leaves of corn seedlings metabolize up to 72% of [14C]pyrimidinyl-labeled diazinon (O,O-diethyl-O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl]phosphorothioate) to 6-methyl-2-(1-methylethyl)-4-hydroxypyrimidine and one unidentified metabolite. Six-day-old corn seedling homogenate had the highest degradative activity. The optimum pH for activity was 6.0 and the activity was found to reside in the cytosol. Etrimfos [O,O-dimethyl-O-(6-ethyl-4-pyrimidinyl)phosphorothioate] was not susceptible to degradation by the corn plant preparation.}, number={2}, journal={Pesticide Biochemistry and Physiology}, author={Ioannou, Y. M. and Dauterman, W. C.}, year={1979}, pages={212} }
 @article{ioannou_dauterman_1979, title={In vitro metabolism of etrimfos by house flies}, volume={10}, DOI={10.1016/0048-3575(79)90005-1}, abstractNote={Abstract The metabolism of etrimfos, O,O -dimethyl- O -(6-ethoxy-2-ethyl-4-pyrimidinyl) phosphorothioate was studied in vitro in a diazinon-resistant (Rutgers) and a susceptible (CSMA) strain of house flies. Practically no metabolism of etrimfos occurred without the addition of cofactors. However, the addition of the cofactor, reduced glutathione, resulted in a substantial amount of metabolism in both strains, the metabolism being higher in the resistant strain. The major route of metabolism was via the glutathione transferase system and the predominant metabolite was desmethyl etrimfos. Although the oxygen analog could not be isolated, microsomal oxidation of etrimfos resulted in the inhibition of acetylcholinesterase, suggesting the formation of the oxygen analog. Bovine serum albumin also degraded etrimfos yielding desmethyl etrimfos and 6-ethoxy-2-ethyl-4-hydroxypyrimidine.}, number={1}, journal={Pesticide Biochemistry and Physiology}, author={Ioannou, Y. M. and Dauterman, W. C.}, year={1979}, pages={31} }