L. M. Johnson

Works (2)

Updated: July 5th, 2023 15:53

1996 journal article

Pharmacokinetic and pharmacodynamic properties of conventional and CD-formulated diltiazem in cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 10(5), 316–320.

By: L. Johnson n, C. Atkins  n, B. Keene n & S. Bai n

TL;DR: It is concluded that DLT at 1 mg/kg p.o. o. sid provide plasma concentrations that are known to have pharmacodynamic effects in other species and heart rate and PR intervals in cats receiving the 2 formulations at steady-state were not different from those measured in the drug-free state. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1995 journal article

THE INFLUENCE OF CIMETIDINE ON THE PHARMACOKINETICS OF THE ENANTIOMERS OF VERAPAMIL IN THE DOG DURING MULTIPLE ORAL DOSING

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 18(2), 117–123.

By: L. Johnson n, S. Lankford n & S. Bai n

MeSH headings : Administration, Oral; Animals; Biological Availability; Blood Proteins / metabolism; Chromatography, High Pressure Liquid; Cimetidine / administration & dosage; Cimetidine / pharmacology; Cross-Over Studies; Dogs / metabolism; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Injections, Intravenous; Protein Binding; Spectrometry, Fluorescence; Stereoisomerism; Verapamil / administration & dosage; Verapamil / blood; Verapamil / chemistry; Verapamil / pharmacokinetics
TL;DR: Cimetidine co-administration significantly reduced the systemic clearance of racemic verapamil as well as that of its enantiomers by 25-29% and the decrease in verAPamil metabolism by cimetidine appeared to be non-stereoselective. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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