@article{lombardi_vandenbergh_1977, title={Pheromonally induced sexual maturation in females: Regulation by the social environment of the male}, volume={196}, number={4289}, journal={Science}, author={Lombardi, J. R. and Vandenbergh, J. G.}, year={1977}, pages={545} } @article{lombardi_vandenbergh_whitsett_1976, title={ANDROGEN CONTROL OF SEXUAL-MATURATION PHEROMONE IN HOUSE MOUSE URINE}, volume={15}, ISSN={["0006-3363"]}, DOI={10.1095/biolreprod15.2.179}, abstractNote={Changes in the capacity of male or female mouse urine to accelerate sexual maturation in female mice were measured following castration and replacement with testosterone propionate (TP). In the male pheromonal activity declined significantly within 2 days after castration and disappeared between 10-15 days. After a single 1.0 mg dose of TP activity reappeared within 24 hours and reached maximum levels within 60 hours. Pheromonal activity showed a significant correlation with urine protein levels. Pheromonal activity androgen-dependent organs and plasma testosterone increased with increasing doses of TP but total urine proteins were not significantly correlated with this activity. The activity of urine from TP-treated females equaled that from males with intact gonads. Pheromonally active urine increased body weight in young females only in some cases. The findings show that the induction and reduction of pheromonal activity is relatively rapid that this activity is dependent on the androgen state of the male and that with androgen stimulation females are capable of pheromone production. Total urine protein levels are correlated with pheromonal activity but pheromonal activity is not a function of total protein concentration in the urine. The androgen control of this system may have significant implications in regulating its function in rodent populations.(AUTHORS MODIFIED)}, number={2}, journal={BIOLOGY OF REPRODUCTION}, author={LOMBARDI, JR and VANDENBERGH, JG and WHITSETT, JM}, year={1976}, pages={179–186} }